Sensation-seeking, life events and depression - The Cardiff Depression Study
Sensation-seeking, life events and depression - The Cardiff Depression Study
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DOI：
10.1192/bjp.178.6.549
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发表时间：
2001-06-01
影响因子：
10.5
通讯作者：
McGuffin, P
中科院分区：
文献类型：
--
作者：
Farmer, A;Redman, K;McGuffin, P
背景逆境与抑郁症遗传风险因素之间的关系可能是由家族“危险倾向”特征介导的，这反映在高水平的感觉寻求上，目的是检查高感觉寻求分数是否与更多导致抑郁的不良生活事件相关。方法在同胞对设计中，对 108 名患有抑郁症的先证者及其兄弟姐妹和 105 名健康对照受试者及其兄弟姐妹的精神病理学、生活事件和分数进行了比较。感觉寻求问卷 (SSQ)。结果 SSQ 分数与抑郁症呈负相关，具有家族性，并且与不太严重的事件呈正相关，但与通常与抑郁症发作相关的严重事件不呈正相关。结论 SSQ 衡量的是家族人格特征，抑郁症与较低的分数相关。虽然高度的感觉寻求与较高的生活事件发生率相关，但这些事件几乎没有威胁。利益声明研究由威康信托基金资助。
Background The relationship between adversity and genetic risk factors in depression could be mediated by familial 'hazard prone' traits, as reflected in high levels of sensation-seeking,Aims To examine whether high sensation-seeking scores are associated with more adverse life events resulting in depression.Method In a sib-pair design, 108 probands with depression and their siblings and 105 healthy control subjects and their siblings were compared for psychopathology, life events and scores on the Sensation-Seeking Questionnaire (SSQ).Results The SSQ scores were correlated negatively with depression, were familial and were correlated positively with less severe events, but not the severe events typically associated with depressive onsets.Conclusions The SSQ measures a familial personality trait and depression is associated with lower scores. Although high sensation-seeking is associated with a higher rate of life events, these carry little threat.Declaration of interest Study Funded by the Wellcome Trust.