The prevalence of potential alcohol-drug interactions in older adults
The prevalence of potential alcohol-drug interactions in older adults
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DOI：
10.3109/02813432.2013.788272
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发表时间：
2013-06-01
影响因子：
2.1
通讯作者：
Pitkala, Kaisu H.
中科院分区：
文献类型：
--
作者：
Immonen, Sirpa;Valvanne, Jaakko;Pitkala, Kaisu H.
目标。本研究的目的是评估 65 岁以上的居家老年人之间发生具有临床意义的药物-酒精相互作用的可能性。设计。这项研究是对芬兰埃斯波 2100 名老年人（≥ 65 岁）分层随机样本的横断面评估。社区居住样本的答复率为 71.6%。这些药物根据其解剖治疗化学 (ATC) 分类索引 (ATC DDD 2012) 进行编码。根据瑞典、芬兰的 INteraction X 参考 (SFINX) 相互作用数据库，以及中枢神经系统药物、降血糖药和华法林与酒精的同时使用，对重要的酒精相互作用 (AI) 药物进行了检查。 “高危饮酒者”被定义为每周饮酒 > 7 杯，或在典型饮酒日饮酒 >= 5 杯，或每周多次饮酒 >= 3 杯，“中度饮酒者”为每月至少饮酒 1 杯，但每周少于 7 杯，“最低限度/不饮酒者”为每月饮酒少于 1 杯。结果。在总样本 (n = 1395) 中，1142 名受访者回答至少使用一种药物。吸毒者中，有 715 人（62.6%）饮酒。 “高危使用者”中的平均药物数量为 4.2 (SD 2.5)，“中度使用者”中的平均药物数量为 4.0 (SD 2.6)，“最低限度/非使用者”中的平均药物数量为 5.4 (SD 3.4) (p < 0.001)。 AI 药物的伴随使用非常普遍。在“高风险用户”、“中等用户”和“最低限度/非用户”中，分别有 42.2%、34.9% 和 52.7% 服用 AI 药物 (p < 0.001)。十分之一的“高危使用者”使用华法林、安眠药/镇静剂或二甲双胍。结论。使用人工智能药物在老年人中很常见，这增加了与饮酒相关的潜在风险。
Objectives. The aim of this study was to assess the possibility of clinically significant drug-alcohol interactions among home-dwelling older adults aged >= 65 years. Design. This study was a cross-sectional assessment of a stratified random sample of 2100 elderly people (>= 65 years) in Espoo, Finland. The response rate was 71.6% from the community-dwelling sample. The drugs were coded according to their Anatomical Therapeutic Chemical (ATC) classification index (ATC DDD 2012). Significant alcohol interactive (AI) drugs were examined according to the Swedish, Finnish, INteraction X-referencing (SFINX) interaction database, as well as concomitant use of central nervous system drugs, hypoglycaemics, and warfarin with alcohol. "At-risk alcohol users" were defined consuming > 7 drinks/week, or >= 5 drinks on a typical drinking day, or using >= 3 drinks several times/week, "moderate users" as consuming at least one drink/month, but less than 7 drinks/week, and "minimal/non-users" less than one drink/month. Results. Of the total sample (n = 1395), 1142 respondents responded as using at least one drug. Of the drug users, 715 (62.6%) persons used alcohol. The mean number of medications was 4.2 (SD 2.5) among "at-risk users", 4.0 (SD 2.6) among "moderate users", and 5.4 (SD 3.4) among "minimal/non-users" (p < 0.001). The concomitant use of AI drugs was widespread. Among the "at-risk users", "moderate users", and "minimal/nonusers" 42.2%, 34.9%, and 52.7%, respectively, were on AI drugs (p < 0.001). One in 10 of "at-risk users" used warfarin, hypnotics/sedatives, or metformin. Conclusions. Use of AI drugs is common among older adults, and this increases the potential risks related to the use of alcohol.