Bortezomib-induced painful neuropathy in patients with multiple myeloma.

Bortezomib-induced painful neuropathy in patients with multiple myeloma.
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DOI:
10.5114/wo.2013.37214
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发表时间:
2013
期刊:
Contemporary oncology (Poznan, Poland)
影响因子:
--
通讯作者:
Pokryszko-Dragan A
Pokryszko-Dragan A
中科院分区:
其他
文献类型:
--
作者:
Bilińska M;Usnarska-Zubkiewicz L;Pokryszko-Dragan A

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对周围神经系统的神经毒性在临床上以疼痛性神经病变的形式出现,是多发性骨髓瘤治疗期间的一个重要剂量限制因素。在这篇评论文章中,这种疼痛性神经病变的不同形式与目前可用的诊断工具,通常用于确认诊断一起提出。此外,最常用的神经量表估计神经功能缺损。特别注意硼替佐米诱导的神经性疼痛的可逆性的管理。
Neurotoxicity towards the peripheral nervous system which appears clinically in the form of painful neuropathy is an essential dose-limiting factor during the treatment of multiple myeloma. In this review article different forms of this painful neuropathy are presented together with currently available diagnostic tools which are usually applied to confirm the diagnosis. Also, the most often used neurological scales estimating neurological deficit are presented. Special attention is paid to the management of the reversibility of bortezomib-induced neuropathic pain.
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