The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.
The paradoxical association of regression with a poor prognosis in melanoma contrasted with a good prognosis in keratoacanthoma.
复制标题
黑色素瘤的消退与不良预后之间的矛盾关系与角化棘皮瘤的良好预后形成鲜明对比。
作者：
R. Prehn
许多观察者（尽管不是全部）报告皮肤恶性黑色素瘤的部分消退与相对较差的预后相关。相比之下，角化棘皮瘤最终会消退，但不会转移。哈蒙德效应可以解释薄型消退黑色素瘤可能预后不良的原因。 Hammond(W.G.Hammond等，Cancer J.，8：130-138，1995)表明，生物进展至低分化表型的速度与肿瘤宿主的免疫能力直接相关。如果部分消退是异常强烈的免疫反应的标志，那么部分消退的黑色素瘤可能具有相对较差的预后，因为存活的肿瘤克隆中生物进展的风险更大。哈蒙德效应与角化棘皮瘤的消退无关。我假设免疫反应会加速而不是抑制肿瘤的生长，并且肿瘤的最终消退不是免疫细胞毒性的结果，而是快速终末分化的结果（反向哈蒙德效应）；或者，非常快速的生长可能会导致生长潜力耗尽，然后才可能发展为克隆永生。
Partial regression in cutaneous malignant melanoma has been reported by a number of observers, albeit not all, to be associated with a relatively poor prognosis; in contrast, a keratoacanthoma, which eventually regresses, does not metastasize. The Hammond effect could explain the possibly poor prognosis of the thin regressing melanoma. Hammond(W.G. Hammond et al., Cancer J., 8: 130-138, 1995) showed that the speed of biological progression to less differentiated phenotypes is directly related to the immunocompetences of the tumor hosts. If partial regression is a sign of an unusually strong immune reaction, then the melanoma that partially regresses might have a relatively poor prognosis because of the greater risk of biological progression among the surviving tumor clones. A Hammond effect is not associated with regression of a keratoacanthoma. I postulate that the growth of this tumor is accelerated, rather than restrained, by the immune reaction and that the ultimate regression of the tumor is the result, not of immune cytotoxicity, but of a rapid terminal differentiation (a reverse Hammond effect); alternatively, very rapid growth might lead to an exhaustion of growth potential before progression to clonal immortality could occur.
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影响因子：
11.2
作者：
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影响因子：
3.3
作者：
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影响因子：
10.3
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
--
作者：
ClarkJr,WH
通讯作者：
ClarkJr,WH