Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine
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DOI：
10.1093/ajcn/78.4.728
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发表时间：
2003-10-01
影响因子：
7.1
通讯作者：
Morgan, LM
中科院分区：
文献类型：
--
作者：
Johnston, KL;Clifford, MN;Morgan, LM
背景资料：越来越多的证据表明，某些膳食多酚在小肠中具有改变葡萄糖摄取模式的生物学效应。然而，它们对人类葡萄糖耐量的影响尚不清楚。目的：目的是研究咖啡中的绿原酸是否能调节人类的葡萄糖摄取、胃肠激素和胰岛素分泌。设计：在一项3向随机交叉研究中，9名健康禁食志愿者在400 mL水（对照）或400 mL含咖啡因或不含咖啡因的咖啡中摄入25 g葡萄糖（相当于2.5 mmol绿原酸/L）。血液样本在以下3小时内频繁地采取。结果：葡萄糖和胰岛素浓度往往是较高的，在第一个30分钟后，含咖啡因的咖啡消费后比消费后的脱咖啡因咖啡或控制（P < 0.05的葡萄糖和胰岛素的曲线下的总面积和增量）。与对照组相比，在整个实验期间，葡萄糖依赖性促胰岛素多肽分泌减少（P < 0.005），而胰高血糖素样肽I分泌在饮用脱咖啡因咖啡后0-120分钟增加（P < 0.01）。葡萄糖和胰岛素曲线与咖啡因的已知代谢效应一致。然而，胃肠道激素的配置文件是一致的延迟肠葡萄糖absorption.Conclusions：血浆葡萄糖，胰岛素和胃肠道激素配置文件的差异进一步证实了咖啡因的有效的生物学作用，并建议绿原酸可能有拮抗作用的葡萄糖转运。因此，一些膳食酚类在人体中的新功能可能是减弱肠道葡萄糖吸收速率，并将葡萄糖吸收部位转移到肠的更远端部分。
Background: Accumulating evidence suggests that certain dietary polyphenols have biological effects in the small intestine that alter the pattern of glucose uptake. Their effects however, on glucose tolerance in humans are unknown.Objective: The objective was to investigate whether chlorogenic acids in coffee modulate glucose uptake and gastrointestinal hormone and insulin secretion in humans.Design: In a 3-way, randomized, crossover study, 9 healthy fasted volunteers consumed 25 g glucose in either 400 mL water (control) or 400 mL caffeinated or decaffeinated coffee (equivalent to 2.5 mmol chlorogenic acid/L). Blood samples were taken frequently over the following 3 h.Results: Glucose and insulin concentrations tended to be higher in the first 30 min after caffeinated coffee consumption than after consumption of decaffeinated coffee or the control (P < 0.05 for total and incremental area under the curve for glucose and insulin). Glucose-dependent insulinotropic polypeptide secretion decreased throughout the experimental period (P < 0.005), and glucagon-like peptide I secretion increased 0-120 min postprandially (P < 0.01) after decaffeinated coffee consumption compared with the control. Glucose and insulin profiles were consistent with the known metabolic effects of caffeine. However, the gastrointestinal hormone profiles were consistent with delayed intestinal glucose absorption.Conclusions: Differences in plasma glucose, insulin, and gastrointestinal hormone profiles further confirm the potent biological action of caffeine and suggest that chlorogenic acid might have an antagonistic effect on glucose transport. Therefore, a novel function of some dietary phenols in humans may be to attenuate intestinal glucose absorption rates and shift the site of glucose absorption to more distal parts of the intestine.