Polyethylene glycol as a cause of anaphylaxis
Polyethylene glycol as a cause of anaphylaxis
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DOI：
10.1186/s13223-016-0172-7
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发表时间：
2016-12-13
影响因子：
2.7
通讯作者：
Worm, Margitta
中科院分区：
文献类型：
--
作者：
Wylon, Katharina;Doelle, Sabine;Worm, Margitta
背景：聚乙二醇(PEGS)或大分子醇是一种聚醚化合物，广泛用作药品、化妆品和食品的添加剂。病例报告：我们报道了一名高加索患者对几种药物反复出现严重过敏反应。进行了广泛的诊断检查，包括皮肤点刺试验、皮内试验(IDT)和双盲口服挑战，以确定过敏反应的触发因素。在目前的病例中，IDT证实了对添加剂聚乙二醇的超敏反应，提示免疫球蛋白E依赖机制是反应的原因。结论：潜在的危及生命的对隐藏分子的超敏反应可能被低估。报告的即刻类型的聚乙二醇型超敏反应的病例越来越多。应提高对聚乙二醇致敏潜力的认识，正确的产品标签是预防聚乙二醇致敏症的关键。
Background: Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food.Case report: We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to identify the trigger of anaphylaxis. In the present case hypersensitivity to the additive polyethylene glycol was confirmed by an IDT suggesting an Immunoglobulin E-dependent mechanism as a cause of the reaction.Conclusion: Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be under-diagnosed. Cases of immediate-type PEG hypersensitivity were reported with increasing frequency. The awareness regarding the allergenic potential of PEG should be raised and a proper product labelling is crucial to prevent PEG mediated hypersensitivity.