INCREASED SOLUBLE INTERLEUKIN-2 RECEPTOR CONCENTRATIONS IN SUICIDE ATTEMPTERS
INCREASED SOLUBLE INTERLEUKIN-2 RECEPTOR CONCENTRATIONS IN SUICIDE ATTEMPTERS
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DOI：
10.1111/j.1600-0447.1993.tb03412.x
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发表时间：
1993-07-01
影响因子：
6.7
通讯作者：
TRASKMANBENDZ, L
中科院分区：
文献类型：
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作者：
NASSBERGER, L;TRASKMANBENDZ, L
一些生化参数（例如单胺和皮质类固醇）被认为在情绪障碍的潜在发病机制中发挥作用。也有人提出，免疫系统的紊乱可能是导致精神障碍的原因。血浆可溶性白细胞介素 2 受体 (S-IL-2R) 浓度的增加反映了 T 淋巴细胞的激活。在患有各种精神疾病（主要是情绪障碍）的未服药自杀企图者的血浆样本中，我们发现 S-IL-2R 浓度中位数远高于健康对照的范围。没有发现性别差异，诊断亚组和自杀亚组之间也没有差异。在后续样本中，S-IL-2R 仍保持在高水平。患者脑脊液样本中，S-IL-2R水平均低于200 U/ml。没有可用的对照样品。我们无法发现血浆 S-IL-2R 与血浆、24 小时尿液和脑脊液中的各种单胺能指标之间存在显着关联。然而，S-IL-2R 与 24 小时尿液中去甲肾上腺素-肾上腺素的比率以及血浆和脑脊液 4-羟基-3-甲氧基甲基乙二醇之间存在关联趋势。地塞米松后血浆皮质醇、24 小时尿皮质醇和血浆 S-IL-2R 之间没有显着相关性。无论是对未接受药物治疗的住院患者进行研究，还是在门诊患者的随访过程中，精神病理学评分与血浆 S-IL-2R 之间均没有明显关联。这项研究清楚地表明，在自杀未遂后研究的精神病患者中存在免疫系统失衡。此外，表现为高S-IL-2R的免疫功能障碍似乎与药物治疗无关。
Several biochemical parameters such as monoamines and corticosteroids are considered to play a role in the underlying pathogenetic mechanisms in mood disorders. It has also been proposed that disturbances of the immune system may be responsible for mental disorders. Increased concentrations of plasma soluble interleukin-2 receptor (S-IL-2R) reflect an activation of T-lymphocytes. In plasma samples from medication-free suicide attempters with various psychiatric diagnoses (mainly mood disorders), we found a median S-IL-2R concentration far above the range of healthy controls. No sex differences and no differences between diagnostic and suicidal subgroups were noted. In follow-up samples, the S-IL-2R remained at high levels. In cerebrospinal fluid samples from patients, S-IL-2R levels were all below 200 U/ml. No samples from controls were available. We were unable to find pronounced associations between plasma S-IL-2R and various monoaminergic measures in plasma, 24-h urine and cerebrospinal fluid. There was, however, a tendency of an association between S-IL-2R and the ratio of norepinephrine-epinephrine in 24-h urine, as well as plasma and cerebrospinal fluid 4-hydroxy-3-methoxymethylglycol. There was no significant association between post-dexamethasone plasma cortisol, 24-h urinary cortisol and plasma S-IL-2R. Both when studied as medication-free inpatients and during follow-up as outpatients, there were no apparent associations between ratings of psychopathology and plasma S-IL-2R. This study clearly shows that an imbalance of the immune system was present in psychiatric patients studied after a suicide attempt. Furthermore, the immune dysfunction, shown as high S-IL-2R, seems to be independent of drug therapy.