Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan.
Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan.
复制标题
在药物遗传学全基因组扫描中使用成对标记组合和递归分区。
DOI：
10.1038/sj.tpj.6500414
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
CNA30027andCNA30032studyteams
中科院分区：
文献类型：
--
作者：
Warren,LL;Hughes,AR;Lai,EH;Zaykin,DV;Haneline,SA;Bansal,AT;Wooster,AW;Spreen,WR;Hernandez,JE;Scott,TR;Roses,AD;Mosteller,M;CNA30027andCNA30032studyteams
药物遗传学研究的目的是确定一个遗传标记，或一组遗传标记，可以预测一个给定的人将如何响应给定的药物。为了寻找这样的标志物组合，是预测药物不良事件，我们已经开发和应用两种互补的方法，以药物遗传学研究的超敏反应（HSR）与阿巴卡韦，一种药物，用于治疗艾滋病病毒感染的患者治疗。我们的研究结果表明，这两种方法都可以用来发现潜在有用的预测标记组合。成对标记组合方法产生了一系列的标记对，其特征在于一系列的敏感性和特异性。递归分区的结果导致多个风险类别，包括极高和极低的HSR风险的遗传划定。这些方法可以很容易地应用于药物遗传学候选基因的研究，以及在全基因组扫描。
The objective of pharmacogenetic research is to identify a genetic marker, or a set of genetic markers, that can predict how a given person will respond to a given medicine. To search for such marker combinations that are predictive of adverse drug events, we have developed and applied two complementary methods to a pharmacogenetic study of the hypersensitivity reaction (HSR) associated with treatment with abacavir, a medicine that is used to treat HIV-infected patients. Our results show that both of these methods can be used to uncover potentially useful predictive marker combinations. The pairwise marker combination method yielded a collection of marker pairs that featured a spectrum of sensitivities and specificities. Recursive partitioning results led to the genetic delineation of multiple risk categories, including those with extremely high and extremely low risk of HSR. These methods can be readily applied in pharmacogenetic candidate gene studies as well as in genome-wide scans.