Factor XIIIa‐positive dermal dendritic cells in keloids and hypertrophic and mature scars
Factor XIIIa‐positive dermal dendritic cells in keloids and hypertrophic and mature scars
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DOI：
10.1111/j.1440-1827.2007.02105.x
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发表时间：
2007-06
影响因子：
2.2
通讯作者：
Masayuki Onodera;M. Ueno;O. Ito;Shigehiko Suzuki;H. Igawa;H. Sakamoto
中科院分区：
文献类型：
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作者：
Masayuki Onodera;M. Ueno;O. Ito;Shigehiko Suzuki;H. Igawa;H. Sakamoto
疤痕疙瘩和增生性疤痕有几个共同特征。两者都是淡红色、坚硬、轻微突出的病变，由增殖的成纤维细胞和胶原组织组成。本研究的目的是评估因子 XIIIa (FXIIIa) 阳性真皮树突细胞对疤痕疙瘩和肥厚性疤痕形成的贡献。计数瘢痕疙瘩、增生性疤痕和成熟疤痕中 FXIIIa 阳性细胞的数量，每个疤痕分为纤维胶原区和覆盖结节性病变的浅层真皮区。使用免疫组织化学和免疫电子显微镜技术检查 FXIIIa 阳性细胞的特征。覆盖真皮区域中存在比纤维胶原区域更多的 FXIIIa 阳性细胞，通常存在于三种类型的真皮病变中。疤痕疙瘩覆盖真皮区域中 FXIIIa 阳性树突状细胞的数量明显多于肥厚性或成熟疤痕的相应区域。免疫电镜检查显示，FXIIIa的免疫反应性主要出现在真皮树突状细胞的细胞质外围。这些结果表明，真皮区域的 FXIIIa 阳性树突状细胞在疤痕疙瘩的形成中发挥着积极作用，并可能有助于疤痕疙瘩中真皮与表皮的相互作用。
Keloids and hypertrophic scars have several common features. Both are reddish, firm, slightly protruding lesions that consist of proliferative fibroblastic cells and collagenous tissues. The aim of the present study was to evaluate the contribution of factor XIIIa (FXIIIa)‐positive dermal dendritic cells to formation of keloids and hypertrophic scars. The numbers of FXIIIa‐positive cells were counted in the keloid, hypertrophic scar and mature scar, each of which was divided into fibrocollagenous area and superficial dermal area overlying the nodular lesion. The features of the FXIIIa‐positive cells were examined using immunohistochemical and immunoelectron microscopic techniques. More FXIIIa‐positive cells were present in the overlying dermal area than in the fibrocollagenous area, commonly in three types of dermal lesion. The number of FXIIIa‐positive dendritic cells was significantly greater in the overlying dermal area of keloids than in the corresponding area of hypertrophic or mature scar. Immunoelectron microscopic examination showed that the immunoreactivity for FXIIIa was seen mainly at the periphery of the cytoplasm of dermal dendritic cells. These results suggest that FXIIIa‐positive dendritic cells in the overlying dermal area play active roles in formation of keloids and may contribute to dermal–epidermal interactions in keloids.