Vitamin D Levels in Subjets With and Without Type 1 Diabetes Residing in a Solar Rich Environment
Vitamin D Levels in Subjets With and Without Type 1 Diabetes Residing in a Solar Rich Environment
复制标题
DOI：
10.2337/dc09-1089
复制
发表时间：
2009-11-01
期刊：
影响因子：
16.2
通讯作者：
Atkinson, Mark
中科院分区：
文献类型：
--
作者：
Bierschenk, Lindsey;Haller, Michael;Atkinson, Mark
研究设计与方法：我们对居住在佛罗里达州的415名居民的血清样本进行了横断面分析：153名对照受试者、46名新发的1型糖尿病患者、110名既往的1型糖尿病患者(样本和GT；结果：在这项研究中，25-羟基维生素D水平(中位数，范围，定量范围[IQR])在对照组(20.1，低于检测范围[BD]-163.5，13.0-37.4 ng/ml)、新发糖尿病患者(21.2，BD-48.6，12.2-30.2 ng/ml)、既往1型糖尿病患者(23.2，BD-263.8，13.8-33.9 ng/ml)、一级亲属(22.2，BD-59.9，12.7~33.1 ng/ml)(P=0.87)。所有研究组的平均25-OH维生素D水平均低于世界卫生组织30 ng/ml的最佳水平。结论血清25-OH维生素D水平降低与1型糖尿病无特异性相关。尽管居住在阳光充足的地区，但均匀的225-OH维生素D水平低于最佳水平，这支持了额外的膳食维生素D强化实践。
OBJECTIVE - Previous studies, largely in northern Europe, have suggested an association between type 1 diabetes and reduced serum 25-hydroxy(OH) vitamin D levels, a concept we tested in individuals residing in a solar-rich region (Florida).RESEARCH DESIGN AND METHODS - Serum samples from 415 individuals residing in Florida were cross-sectionally analyzed: 153 control subjects, 46 new-onset type 1 diabetic patients, 110 established type 1 diabetic patients (samples >= 5 months from diagnosis), and 1.06 first-degree relatives of the diabetic patients.RESULTS - In this study, 25-OH vitamin D levels (median, range, interquanile range [IQR]) were similar among control subjects (20.1, below detection [bd]-163.5, 13.0-37.4 ng/ml), new-onset type 1. diabetic patients (21.2, bd-48.6,12.2-30.2 ng/ml), established type 1 diabetic patients (23.2, bd-263.8, 13.8-33.9 ng/ml), and first-degree relatives (22.2, bd-59.9, 12.7-33.1 ng/ml) (P = 0.87). Mean 25-OH vitamin D levels were less than the optimal World Health Organization level of 30 ng/ml in all study groups.CONCLUSIONS - Reduced serum 25-OH vitamin D levels were not specifically associated with type 1 diabetes. The uniform suboptimal 225-OH vitamin D levels, despite residence in a zone with abundant sunshine, support additional dietary vitamin D fortification practices.