Intensity-based volumetric registration of magnetic resonance images and whole-mount sections of the prostate
Intensity-based volumetric registration of magnetic resonance images and whole-mount sections of the prostate
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DOI：
10.1016/j.compmedimag.2017.12.002
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发表时间：
2018-01-01
影响因子：
5.7
通讯作者：
Lundervold, Arvid
中科院分区：
文献类型：
--
作者：
Losnegard, Are;Reisaeter, Lars;Lundervold, Arvid
目的：前列腺的磁共振成像（MRI）提供了有用的体内诊断组织信息，如肿瘤位置和侵袭性，但离体组织病理学仍然是基础事实。MRI与组织病理学的配准存在若干挑战。我们提出了一种方法，用于注册的标准临床T2加权MRI（T2 W-MRI）和横向组织病理学整体安装（WM）节prostate.Methods：一个各向同性的体积堆栈创建从WM部分使用2D刚性和变形配准结合线性插值。从T2 W-MRI体积手动分割前列腺，并使用仿射和变形配准的组合将其配准到WM切片体积。该方法进行了评估的一组12例患者进行了根治性直肠癌切除术。配准精度进行了评估，使用体积重叠（Dice系数，DC）和界标distance.Results：DC为0.94为整个前列腺，0.63为周边区和0.77为其余腺体。标志距离平均为5.4 mm。结论：整个前列腺和剩余腺体的体积重叠以及标志距离表明所提出的方法具有良好的配准准确性，并表明它对于配准临床可用的MRI和WM非常有用。前列腺切片。
Objective: Magnetic Resonance Imaging (MRI) of the prostate provides useful in vivo diagnostic tissue information such as tumor location and aggressiveness, but ex vivo histopathology remains the ground truth. There are several challenges related to the registration of MRI to histopathology. We present a method for registration of standard clinical T2-weighted MRI (T2W-MRI) and transverse histopathology whole-mount (WM) sections of the prostate.Methods: An isotropic volume stack was created from the WM sections using 2D rigid and deformable registration combined with linear interpolation. The prostate was segmented manually from the T2W-MRI volume and registered to the WM section volume using a combination of affine and deformable registration. The method was evaluated on a set of 12 patients who had undergone radical prostatectomy. Registration accuracy was assessed using volume overlap (Dice Coefficient, DC) and landmark distances.Results: The DC was 0.94 for the whole prostate, 0.63 for the peripheral zone and 0.77 for the remaining gland. The landmark distances were on average 5.4 mm.Conclusion: The volume overlap for the whole prostate and remaining gland, as well as the landmark distances indicate good registration accuracy for the proposed method, and shows that it can be highly useful for registering clinical available MRI and WM sections of the prostate.