Clinical presentation of hospitalized adult patients with HIV infection and AIDS in Bangkok, Thailand
Clinical presentation of hospitalized adult patients with HIV infection and AIDS in Bangkok, Thailand
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DOI：
10.1097/00126334-199908010-00011
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发表时间：
1999-08-01
期刊：
影响因子：
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通讯作者：
Mastro, TD
中科院分区：
文献类型：
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作者：
Tansuphasawadikul, S;Amornkul, PN;Mastro, TD
目的：描述曼谷成人HIV-1感染患者的临床疾病谱和免疫状态，设计：对住院患者进行横断面调查，方法：从1993年11月到1996年6月，收集HIV感染住院患者的人口统计学、临床和实验室数据（大于或等于14岁）在传染病医院。在16 717名住院病人中，有3 112人（18.6%）艾滋病毒血清反应呈阳性，其中2 261人是首次住院。在2261人中，1926人（85.2%）为男性，1942人（85.9%）为异性性感染或通过与吸毒无关的方式感染，319人（14.1%）为注射吸毒者（IDUs），1553人（68.7%）患有艾滋病。最常见的艾滋病定义的条件是肺外隐球菌病（EPC; 38.4%），结核病（TB; 37.4%），消耗综合征（NS; 8.1%）。与没有注射吸毒史的患者相比，注射吸毒者更可能（p <0.05）患结核病或WS，但患EPC或卡氏肺孢子虫肺炎的可能性较小（p <0.05）。淋巴细胞计数测量2047（90.5%）例; 81.8%的小于或等于1500淋巴细胞/μ l。结论：这些HIV感染者入院时严重的免疫抑制。隐球菌病和结核病是主要问题，在注射吸毒者和性感染者中流行率不同。临床和免疫学信息对于通过预防、治疗和预防措施改善亚洲艾滋病毒感染者的生活至关重要。
Objective: To characterize the clinical spectrum of disease and immune status of adult HIV-1-infected patients in Bangkok.Design: Cross-sectional survey of hospital admissions.Methods: From November 1993 through June 1996, demographic, clinical, and laboratory data were collected from HIV-infected inpatients (greater than or equal to 14 years old) at an infectious diseases hospital.Results: Of 16,717 persons admitted, 3112(18.6%) were HIV-seropositive, 2261 of whom were admitted for the first time. Of 2261, 1926 (85.2%) were male, 1942 (85.9%) had been infected heterosexually or by means not related to drug use, 319 (14.1%) were injection drug users (IDUs), and 1553 (68.7%) had AIDS. The most common AIDS-defining conditions were extrapulmonary cryptococcosis (EPC; 38.4%), tuberculosis (TB; 37.4%), and wasting syndrome (NS; 8.1%). IDUs were more likely (p < .05) to have TB or WS but less likely (p < .05) to have EPC or Pneumocystis carinii pneumonia than patients with no history of injection drug use. Lymphocyte counts were measured for 2047 (90.5%) patients; 81.8% had less than or equal to 1500 lymphocytes/mu l.Conclusion: These HIV-infected patients were admitted with severe immunosuppression. Cryptococcosis and TB are major problems and differ in prevalence among IDUs and persons infected sexually. Clinical and immunologic information is critical in improving the lives of HIV-infected persons in Asia through prevention, treatment, and prophylaxis.