Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology.
Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology.
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DOI：
10.1016/j.pt.2021.02.007
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发表时间：
2021-06
影响因子：
9.6
通讯作者：
Fidock DA
中科院分区：
文献类型：
--
作者：
Okombo J;Kanai M;Deni I;Fidock DA
Recent progress in genomics and molecular genetics has empowered novel approaches to closely study gene functions in disease-causing pathogens. In the human malaria parasite Plasmodium falciparum, the application of genome-based analyses, site-directed genome editing, and genetic systems that allow for temporal and quantitative regulation of gene and protein expression have been invaluable in defining the genetic basis of antimalarial resistance and elucidating candidate targets to accelerate drug discovery efforts. Using examples from recent studies, we review applications of some of these approaches in advancing our understanding of Plasmodium biology and illustrate their contributions and limitations in characterizing parasite genomic loci associated with antimalarial drug responses.
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影响因子：
15.8
作者：
Chen I;Clarke SE;Gosling R;Hamainza B;Killeen G;Magill A;O'Meara W;Price RN;Riley EM
通讯作者：
Riley EM
与柬埔寨恶性疟原虫疟疾双氢青蒿素-哌喹失败相关的遗传标记：基因型-表型关联研究。
DOI：
10.1016/s1473-3099(16)30409-1
发表时间：
2017-03
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Amato R;Lim P;Miotto O;Amaratunga C;Dek D;Pearson RD;Almagro-Garcia J;Neal AT;Sreng S;Suon S;Drury E;Jyothi D;Stalker J;Kwiatkowski DP;Fairhurst RM
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Fairhurst RM
影响因子：
6.4
作者：
Barros, Roberto R. Moraes;Straimer, Judith;Wellems, Thomas E.
通讯作者：
Wellems, Thomas E.
影响因子：
12.3
作者：
Cerqueira GC;Cheeseman IH;Schaffner SF;Nair S;McDew-White M;Phyo AP;Ashley EA;Melnikov A;Rogov P;Birren BW;Nosten F;Anderson TJC;Neafsey DE
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Neafsey DE
影响因子：
14.8
作者：
Brancucci, Nicolas M. B.;Goldowitz, Ilana;Marti, Matthias
通讯作者：
Marti, Matthias