Eosinophilic tracheobronchitis with cough hypersensitivity caused by Streptomyces albus antigen
Eosinophilic tracheobronchitis with cough hypersensitivity caused by Streptomyces albus antigen
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白色链霉菌抗原引起的嗜酸性气管支气管炎伴咳嗽过敏
DOI：
10.1046/j.1440-1592.2000.00157.x
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发表时间：
2000
影响因子：
6.8
通讯作者：
T. Matsuda
中科院分区：
文献类型：
--
作者：
H. Ogawa;M. Fujimura;Saori Myou;M. Kitagawa;T. Matsuda
我们报告一位52岁的女性特应性咳嗽，她的支气管诱发白色链霉菌抗原引起的咳嗽和支气管镜活检显示嗜酸性气管支气管炎。她因严重非生产性咳嗽被诊断和治疗。虽然她的诱导痰中含有8%的嗜酸性粒细胞有核细胞，支气管镜活检标本显示气管和支气管壁均有嗜酸性粒细胞浸润，但她没有支气管对甲胆碱的高反应性或支气管运动性张力增高。支气管扩张剂治疗对她的咳嗽无效。她的症状在回家后恶化，这表明她的房子里存在一些病原体。从她家分离出白色链霉菌。高滴度抗s。血清中检测到白脓杆菌抗体，白脓杆菌抗原支气管激发试验阳性：15 min后出现咳嗽，24 h后吸入辣椒素的咳嗽阈值从31.3 μmol/L降低至3.9 μmol/L。本文首次报道嗜酸性气管支气管炎伴白念珠菌抗原过敏反应引起的咳嗽超敏反应。
A 52-year-old woman is reported with atopic cough, in whom bronchoprovocation with Streptomyces albus antigen induced cough and bronchoscopic biopsy revealed eosinophilic tracheobronchitis. She was admitted for the diagnosis and treatment of severe non-productive cough. Although her induced sputum contained 8% eosinophils of nucleated cells and bronchoscopic biopsy specimens revealed eosinophil infiltration in both tracheal and bronchial wall, she did not have bronchial hyperresponsiveness to methacholine or heightened bronchomotor tone. Bronchodilator therapy was not effective for her coughing. Her symptoms worsened on returning home, suggesting the existence of some etiologic agents in her house. Streptomyces albus was isolated from her house. A high titer of anti-S. albus antibody was detected in her serum and the bronchoprovocation test with S. albus antigen was positive: development of coughing 15 min later and decrease in cough threshold to inhaled capsaicin 24 h later (3.9 μmol/L from 31.3 μmol/L prechallenge). This is the first report on eosinophilic tracheobronchitis with cough hypersensitivity caused by allergic reaction to S. albus antigen.