Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef
Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef
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DOI：
10.1038/15224
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发表时间：
1999-11-01
期刊：
影响因子：
82.9
通讯作者：
Watkins, DI
中科院分区：
文献类型：
--
作者：
Evans, DT;O'Connor, DH;Watkins, DI
对人类免疫缺陷病毒的细胞毒性T淋巴细胞（CTL）反应在感染后早期出现，但最终未能阻止艾滋病的进展。人类免疫缺陷病毒可以通过在CTL表位内积累氨基酸替换来逃避CTL应答。我们研究了10个CTL表位在三个相关的猕猴猴免疫缺陷病毒疾病进展的过程中。所有10个CTL表位积累了氨基酸替换，并在猕猴死亡时显示出阳性选择的证据。这些表位中的许多氨基酸替换减少或消除了主要组织相容性复合物I类结合和/或CTL识别。这些发现强烈支持CTL“逃逸”假说。
Cytotoxic T-lymphocyte (CTL) responses to human immunodeficiency virus arise early after infection, but ultimately fail to prevent progression to AIDS. Human immunodeficiency virus may evade the CTL response by accumulating amino-acid replacements within CTL epitopes. We studied 10 CTL epitopes during the course of simian immunodeficiency virus disease progression in three related macaques. All 10 of these CTL epitopes accumulated amino-acid replacements and showed evidence of positive selection by the time the macaques died. Many of the amino-acid replacements in these epitopes reduced or eliminated major histocompatibility complex class I binding and/or CTL recognition. These findings strongly support the CTL 'escape' hypothesis.