Functional dissection of the neural substrates for gravitaxic maze behavior in Drosophila melanogaster
Functional dissection of the neural substrates for gravitaxic maze behavior in Drosophila melanogaster
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DOI：
10.1002/cne.21257
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发表时间：
2007-04-10
影响因子：
2.5
通讯作者：
Armstrong, James Douglas
中科院分区：
文献类型：
--
作者：
Baker, Dean Adam;Beckingham, Kathleen Mary;Armstrong, James Douglas
在动物中，重力感应是由机械感觉神经元支持的，机械感觉神经元将信息发送到中枢大脑，以便与其他模式进行整合。在果蝇中，根据最近的正向遗传筛选的结果预测了用于检测重力矢量的候选感觉器官。该分析还表明了果蝇中央复合体和触角系统的可能作用。使用与原始屏幕中使用的相同的垂直迷宫测定，我们通过 GAL4/UAS-shibire[ts1] 系统突触传递的空间和时间失活来研究这些候选神经结构的作用。我们将果蝇迷宫行为的变化与关键脑神经纤维（包括中央复合体和触球小球束）突触传递的特异性抑制联系起来。此外，我们的结果表明蘑菇体的作用很小，或者根本不存在。
In animals, sensing gravity is supported by mechanosensory neurons that send information to the central brain for integration along with other modalities. In Drosophila, candidate sensory organs for detecting the gravity vector were predicted from the results of a recent forward genetic screen. This analysis also suggested possible roles for the central complex and antennal system in Drosophila. Using the same vertical maze assay employed in the original screen, we investigated the roles of these candidate neural structures by spatial and temporal inactivation of synaptic transmission with the GAL4/UAS-shibire[ts1] system. We correlate changes in the maze behavior of flies with specific inhibition of synaptic transmission for key brain neuropil that includes the central complex and antennoglomerular tract. Further, our results point toward a minimal, or nonexistent, role for the mushroom bodies.