Ganoderic Acids from Ganoderma lucidum: Inhibitory Activity of Osteoclastic Differentiation and Structural Criteria
Ganoderic Acids from Ganoderma lucidum: Inhibitory Activity of Osteoclastic Differentiation and Structural Criteria
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DOI：
10.1055/s-0029-1186035
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发表时间：
2010-01-01
期刊：
影响因子：
2.7
通讯作者：
Kondo, Ryuichiro
中科院分区：
文献类型：
--
作者：
Liu, Jie;Shiono, Jun;Kondo, Ryuichiro
骨吸收增加在许多骨疾病的发病机制中起着重要作用。灵芝是众所周知的药用效果，如抗炎和抗骨吸收的活动。本实验研究了从灵芝中提取的灵芝酸对大肠杆菌的生长抑制作用。灵芝对体外培养的RAW264细胞成骨分化的影响C7中的羰基对于引起破骨细胞分化的抑制是必不可少的。
Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone resorption activities. In this study, we investigated the inhibitory effects of ganoderic acids isolated from G. lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation.