Influence of Short-Range Scrambling of Monomer Order on the Hydrolysis Behaviors of Sequenced Degradable Polyesters
Influence of Short-Range Scrambling of Monomer Order on the Hydrolysis Behaviors of Sequenced Degradable Polyesters
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DOI：
10.1021/acs.macromol.9b00480
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发表时间：
2019-06
期刊：
影响因子：
5.5
通讯作者：
J. Nowalk;Jordan H. Swisher;T. Meyer
中科院分区：
文献类型：
--
作者：
J. Nowalk;Jordan H. Swisher;T. Meyer
单体序列的微小变化在多大程度上影响生物大分子的行为是定期研究，但小序列的变化的整体性能的依赖性是underexplored的合成共聚物。这种类型的调查是有限的，所需的艰巨的合成，缺乏可扩展性，和已知的聚合物系统的例子，表现出敏感的序列/性能的依赖性稀缺。我们的小组先前已经探索了测序的聚（乳酸-羟基乙酸）文库的水解行为，并发现与L-G序列有很强的相关性。为了研究该系统中相对短程序列变化在多大程度上控制了性能，我们将精确测序和轻度“乱序”L-G低聚物纳入环状大分子单体中，并将其进行熵驱动的开环易位聚合，我们最近展示的一种方法是生产具有分子量控制和序列重排的聚合物。
The extent to which small changes in monomer sequence affect the behaviors of biological macromolecules is studied regularly, yet the dependence of bulk properties on small sequence alterations is underexplored for synthetic copolymers. Investigations of this type are limited by the arduous syntheses required, lack of scalability, and scarcity of examples of polymer systems that are known to exhibit sensitive sequence/property dependencies. Our group has previously explored the hydrolysis behaviors of a library of sequenced poly(lactic-co-glycolic acid)s and found a strong correlation with the L–G sequence. To investigate the degree to which properties are dominated in this system by relatively short-range sequence changes, we have incorporated precisely sequenced and mildly “scrambled” L–G oligomers into cyclic macromonomers and subjected them to entropy-driven ring-opening metathesis polymerization, a method that we have recently shown produces polymers with molecular weight control and sequence preserv...