Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment.
Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment.
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发表时间：
2012
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通讯作者：
D. Leyva-Illades;Matthew McMillin;M. Quinn;S. DeMorrow
中科院分区：
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作者：
D. Leyva-Illades;Matthew McMillin;M. Quinn;S. DeMorrow
胆管癌是一种起源于肝内或肝外胆管上皮细胞的肿瘤性转化的肿瘤。这种类型的癌症很难诊断，极具侵略性，预后非常差。它对化疗和放疗也有相对抵抗力。其发病机制知之甚少，但已知肿瘤微环境是调节肿瘤血管生成、侵袭和转移的非常重要的因素。这些事件的调节机制以及肿瘤微环境在胆管癌的发病机制和分类中的作用，将讨论目前的知识。
Cholangiocarcinoma is a tumor that originates from the neoplastic transformation of the epithelial cells of the intrahepatic or extrahepatic bile ducts. This type of cancer is difficult to diagnose, extremely aggressive, and has very poor prognosis. It is also relatively resistant to chemotherapy and radiation therapy. Its pathogenesis is poorly understood, however it is known that the tumor microenvironment is a very important factor in the regulation of tumor angiogenesis, invasion, and metastasis. The current knowledge about the mechanisms by which these events are regulated as well as the role of the tumor microenvironment in the pathogenesis and classification of cholangiocarcinoma will be discussed.