Functional imaging and anatomical connections in squirrel monkeys reveal parietal-frontal circuits underlying eye movements.
Functional imaging and anatomical connections in squirrel monkeys reveal parietal-frontal circuits underlying eye movements.
复制标题
DOI：
10.1093/cercor/bhad036
复制
发表时间：
2023-02
期刊：
影响因子：
3.7
通讯作者：
I. Stepniewska;Sofia Kahler-Quesada;J. Kaas;R. Friedman
中科院分区：
文献类型：
--
作者：
I. Stepniewska;Sofia Kahler-Quesada;J. Kaas;R. Friedman
松鼠猴的后顶叶皮层（PPC）包含长列皮质内微刺激引起复杂的，行为上有意义的运动的子区域。最近，我们发现，这种刺激的一部分PPC在尾侧沟（LS）eladened这些猴子的眼球运动。在这里，我们研究了这个我们称之为顶叶眼场（PEF）与额叶眼场（FEF）和其他皮质区域的功能和解剖联系在2只松鼠猴。我们用内在光学成像和注射解剖示踪剂证明了这些联系。在PEF刺激过程中额叶皮层的光学成像引起FEF内的局灶性功能激活。追踪研究证实了功能性PEF-FEF连接。此外，示踪剂注射显示PEF连接与其他PPC区域的背外侧和内侧大脑表面，皮质在尾部LS，视觉和听觉皮层的关联领域。PEF的皮质下投射主要集中在上级丘、脑桥核、丘脑背后核和尾状核。这些研究结果表明，在松鼠猴的PEF是同源的外侧顶内（LIP）区的猕猴，支持的概念，这些脑回路的组织类似，以介导行为学相关的眼行为。
The posterior parietal cortex (PPC) of squirrel monkeys contains subregions where long trains of intracortical microstimulation evoke complex, behaviorally meaningful movements. Recently, we showed that such stimulation of a part of the PPC in the caudal lateral sulcus (LS) elicits eye movements in these monkeys. Here, we studied the functional and anatomical connections of this oculomotor region we call parietal eye field (PEF) with frontal eye field (FEF) and other cortical regions in 2 squirrel monkeys. We demonstrated these connections with intrinsic optical imaging and injections of anatomical tracers. Optical imaging of frontal cortex during stimulation of the PEF evoked focal functional activation within FEF. Tracing studies confirmed the functional PEF-FEF connections. Moreover, tracer injections revealed PEF connections with other PPC regions on the dorsolateral and medial brain surface, cortex in the caudal LS, and visual and auditory cortical association areas. Subcortical projections of PEF were primarily with superior colliculus, and pontine nuclei as well as nuclei of the dorsal posterior thalamus and caudate. These findings suggest that PEF in squirrel monkey is homologous to lateral intraparietal (LIP) area of macaque, supporting the notion that these brain circuits are organized similarly to mediate ethologically relevant oculomotor behaviors.