Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study
Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study
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DOI：
10.1016/s0896-6273(00)80475-4
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发表时间：
1998-05-01
期刊：
影响因子：
16.2
通讯作者：
Phelps, EA
中科院分区：
文献类型：
--
作者：
LaBar, KS;Gatenby, JC;Phelps, EA
本研究采用平面回波功能磁共振成像（fMRI）技术，对正常人杏仁核在条件性恐惧获得和消退中的作用进行了研究。一个简单的歧视程序，其中激活的视觉线索预测休克（CS+）与激活的另一个线索单独（CS-）进行了比较。CS+和CS-试验类型以伪随机顺序混合。功能图像采集与不对称的自旋回波脉冲序列从三个冠状切片杏仁核为中心。在条件性恐惧获得和消退过程中观察到杏仁核/杏仁核周围皮质的激活。在收购过程中的激活程度显着相关的自律指标的条件反射在个别科目。与最近在大鼠中的电生理记录研究一致（Quirk等人，1997），杏仁核反应的轮廓是暂时分级的，尽管这种动态仅在灭绝期间是统计学上可靠的。这些结果提供了进一步的证据杏仁核功能的保护跨物种和牵连杏仁核的贡献收购和灭绝过程中的联想情绪学习任务。
Echoplanar functional magnetic resonance imaging (fMRI) was used in normal human subjects to investigate the role of the amygdala in conditioned fear acquisition and extinction. A simple discrimination procedure was employed in which activation to a visual cue predicting shock (CS+) was compared with activation to another cue presented alone (CS-). CS+ and CS-trial types were intermixed in a pseudorandom order. Functional images were acquired with an asymmetric spin echo pulse sequence from three coronal slices centered on the amygdala. Activation of the amygdala/periamygdaloid cortex was observed during conditioned fear acquisition and extinction. The extent of activation during acquisition was significantly correlated with autonomic indices of conditioning in individual subjects. Consistent with a recent electrophysiological recording study in the rat (Quirk et at., 1997), the profile of the amygdala response was temporally graded, although this dynamic was only statistically reliable during extinction. These results provide further evidence for the conservation of amygdala function across species and implicate an amygdalar contribution to both acquisition and extinction processes during associative emotional learning tasks.