A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs
A comparison between astemizole and other antihistamines on sleep-wakefulness cycles in dogs
复制标题
阿司咪唑和其他抗组胺药对狗睡眠-觉醒周期的比较
DOI：
10.1016/0028-3908(81)90078-2
复制
发表时间：
1981
影响因子：
4.7
通讯作者：
P. Janssen
中科院分区：
文献类型：
--
作者：
A. Wauquier;Wim Van den Broeck;F. Awouters;P. Janssen
本文研究了酮替芬、苯海拉明、扑尔敏、吡拉明和新型长效抗组胺药阿司咪唑对同一种狗16小时睡眠-觉醒模式的影响。使用基于计算机的在线分析和自动阶段分类，在觉醒、向睡眠过渡（困倦）、慢波睡眠和快速眼动（REM）睡眠之间进行区分。参比抗组胺药显著增加非REM睡眠。参考抗组胺药显着增加非REM睡眠：苯海拉明和扑尔敏增加嗜睡，酮替芬增加慢波睡眠和吡拉明增加两者。除阿司咪唑外，所有药物都显著延长了第一个REM期的潜伏期，延长了连续REM期之间的间隔，并抑制了REM睡眠的总量。所有抗组胺药，效果最明显的前4小时，并没有夜间反弹。扑尔敏在整个晚上都有持久的效果，特别是对REM睡眠。对非快速眼动睡眠的影响可能是由于大脑组胺H1受体的阻断，而对快速眼动睡眠的影响可能是由于抗组胺药的抗胆碱能特性。阿司咪唑对睡眠-觉醒模式没有任何显著影响，尽管其具有持久的抗组胺作用，这表明抗组胺药的常见临床副作用，如镇静和粘膜表面干燥，将缺乏。
The effects of four reference antihistamines: ketotifen, diphenhydramine, chlorpheniramine and pyrilamine and of astemizole, a new potent and long-acting antihistamine, were studied on 16 hr sleep-wakefulness patterns in the same dogs. Using a computer-based on-line analysis and automatic stage classification, a differentiation was made between wakefulness, transition to sleep (drowsiness), slow wave sleep and rapid eye movement (REM) sleep. The reference antihistamines significantly increased non-REM sleep. The reference antihistamines significantly increased non-REM sleep: diphenhydramine and chlorpheniramine increased drowsiness, ketotifen increased slow-wave sleep and pyrilamine increased both. All, but astemizole, significantly prolonged the latency to the first REM period, prolonged the interval between successive REM periods and suppressed the total amount of REM sleep. With all antihistamines, the effects were most pronounced for the first 4 hr and there was no within-night rebound. Chlorpheniramine had long-lasting effects throughout the night, especially on REM sleep. The effects on non-REM sleep might be due to a blockage of brain histamine H1receptors, whereas the effects on REM sleep might be due to the anticholinergic properties of the antihistamines. Astemizole was devoid of any significant effect on the sleep-wakefulness pattern, in spite of its long-lasting antihistamine effects, suggesting that the common clinical side-effects of antihistamines, such as sedation and dryness of mucosal surfaces, will be lacking.