The rewards of music listening: Response and physiological connectivity of the mesolimbic system
The rewards of music listening: Response and physiological connectivity of the mesolimbic system
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DOI：
10.1016/j.neuroimage.2005.05.053
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发表时间：
2005-10-15
期刊：
影响因子：
5.7
通讯作者：
Levitin, DJ
中科院分区：
文献类型：
--
作者：
Menon, V;Levitin, DJ
尽管音乐认知的神经基础在过去五年中得到了广泛的研究，但人们对音乐在听众中引起的情绪反应背后的神经科学知之甚少。许多人花大量的时间听音乐，其情感力量被假定但没有得到很好的理解。在这里，我们使用功能和有效的连接分析首次表明，听音乐强烈调节参与奖励处理的中脑边缘结构网络的活动，包括伏隔核（NAc）和腹侧被盖区（VTA），以及下丘脑和岛叶，这些区域被认为参与调节对奖励和情绪刺激的自主和生理反应。 NAc 和 VTA 的反应密切相关，表明多巴胺释放与 NAc 对音乐的反应之间存在关联。 NAc 和下丘脑的反应在受试者之间也有很强的相关性，这表明听愉快的音乐会引起生理反应。有效的连接证实了这些发现，并显示 NAc 与下丘脑、岛叶和眶额皮质之间有显着的 VTA 介导的相互作用。调节奖励、自主和认知处理的大脑区域之间增强的功能和有效连接有助于深入理解为什么听音乐是最有价值和最愉快的人类体验之一。 (c) 2005 Elsevier Inc. 保留所有权利。
Although the neural underpinnings of music cognition have been widely studied in the last 5 years, relatively little is known about the neuroscience underlying emotional reactions that music induces in listeners. Many people spend a significant amount of time listening to music, and its emotional power is assumed but not well understood. Here, we use functional and effective connectivity analyses to show for the first time that listening to music strongly modulates activity in a network of mesolimbic structures involved in reward processing including the nucleus accumbens (NAc) and the ventral tegmental area (VTA), as well as the hypothalamus and insula, which are thought to be involved in regulating autonomic and physiological responses to rewarding and emotional stimuli. Responses in the NAc and the VTA were strongly correlated pointing to an association between dopamine release and NAc response to music. Responses in the NAc and the hypothalamus were also strongly correlated across subjects, suggesting a mechanism by which listening to pleasant music evokes physiological reactions. Effective connectivity confirmed these findings, and showed significant VTA-mediated interaction of the NAc with the hypothalamus, insula, and orbitofrontal cortex. The enhanced functional and effective connectivity between brain regions mediating reward, autonomic, and cognitive processing provides insight into understanding why listening to music is one of the most rewarding and pleasurable human experiences. (c) 2005 Elsevier Inc. All rights reserved.