Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test
Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test
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DOI：
10.1016/j.pnpbp.2012.10.024
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发表时间：
2013-03-05
影响因子：
5.6
通讯作者：
Abilio, Vanessa C.
中科院分区：
文献类型：
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作者：
Almeida, Valeria;Levin, Raquel;Abilio, Vanessa C.
大麻二酚 (CBD) 是大麻的一种非拟精神病化合物，据报道具有重要的治疗作用，例如抗精神病和抗焦虑作用。我们最近报道，自发性高血压大鼠（SHR）表现出社交互动缺陷，非典型抗精神病药物可以改善这种缺陷。此外，SHR 呈现出典型和非典型抗精神病药物可恢复的过度运动，这表明该菌株可用于研究精神分裂症的阴性症状（以社交互动减少为模型）和阳性症状（以过度运动为模型）以及潜在抗精神病药物的作用。与此同时，对照动物中社交互动的增加类似于苯二氮卓类药物引起的社交互动的增加，用于筛选潜在的抗焦虑药物。本研究的目的是调查 CBD 对对照动物 (Wistar) 和 SHR 社交互动的影响。最低剂量的 CBD（1 毫克/千克）增加了 Wistar 大鼠的被动和总体社交互动。然而，任何剂量的 CBD 都不会改变 SHR 表现出的过度运动和社交互动缺陷。我们的结果并不支持大麻二酚对 SHR 中症状样行为的抗精神病特性，但强化了该化合物在对照大鼠中的抗焦虑作用。 (C) 2012 Elsevier Inc. 保留所有权利。
Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. In addition, SHRs present a hyperlocomotion that is reverted by typical and atypical antipsychotics, suggesting that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and positive symptoms (modeled by hyperlocomotion) of schizophrenia as well as the effects of potential antipsychotics drugs. At the same time, an increase in social interaction in control animals similar to that induced by benzodiazepines is used to screen potential anxiolytic drugs. The aim of this study was to investigate the effects of CBD on social interaction presented by control animals (Wistar) and SHRs. The lowest dose of CBD (1 mg/kg) increased passive and total social interaction of Wistar rats. However, the hyperlocomotion and the deficit in social interaction displayed by SHRs were not altered by any dose of CBD. Our results do not support an antipsychotic property of cannabidiol on symptoms-like behaviors in SHRs but reinforce the anxiolytic profile of this compound in control rats. (C) 2012 Elsevier Inc. All rights reserved.