Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
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DOI：
10.1136/bmj.38380.674340.e0
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发表时间：
2005-03-12
影响因子：
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通讯作者：
Harrington, D
中科院分区：
文献类型：
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作者：
Duckitt, K;Harrington, D
目的确定与产前预约时可能存在的因素相关的先兆子痫风险。设计对1966- 2002年发表的对照研究进行系统回顾。数据综合根据已发表的数据计算未调整的相对风险。结果对照队列研究表明，先兆子痫的风险在有先兆子痫病史的女性中增加（相对危险度7.19，95%置信区间5.85 - 8.83）和抗磷脂抗体阳性者（9.72，4.34 ~ 21.75），既往糖尿病（3.56，2.54至4.99），多胎（双胎）妊娠（2.93，2.04至4.2 1），未产（2.9 1，1.28至6.61），家族史（2.90，1.70至4.93），血压升高（舒张压>= 80 min Hg）（1.38，1.01 ~ 1.87），孕前体重指数升高（2.47，1.66至3.67）或预约时（1.55，1.28至1.88），或母亲年龄≥ 40岁（1.96，1.34至2.87）的经产妇女。个别研究表明，风险也增加了10年或更长的时间间隔，因为以前的怀孕，自身免疫性疾病，肾脏疾病，慢性hypertension.Conclusions这些因素和潜在的证据基础可以用来评估风险在预订，以便一个合适的监测常规检测先兆子痫可以计划在怀孕的其余部分。
Objective To determine the risk of pre-eclampsia associated with factors that may be present at antenatal booking.Design Systematic review of controlled studies published 1966-2002.Data synthesis Unadjusted relative risks were calculated from published data.Results Controlled cohort studies showed that the risk of pre-eclampsia is increased in women with a previous history of pre-eclampsia (relative risk 7.19, 95% confidence interval 5.85 to 8.83) and in those with antiphospholipid antibodies (9.72,4.34 to 21.75), pre-existing diabetes (3.56, 2.54 to 4.99), multiple (twin) pregnancy (2.93, 2.04 to 4.2 1), nulliparity (2.9 1, 1.28 to 6.61), family history (2.90, 1.70 to 4.93), raised blood pressure (diastolic >= 80 min Hg) at booking (1.38, 1.01 to 1.87), raised body mass index before pregnancy (2.47, 1.66 to 3.67) or at booking (1.55, 1.28 to 1.88), or maternal age >= 40 (1.96, 1.34 to 2.87) for multiparous women. Individual studies show that risk is also increased with an interval of 10 years or more since a previous pregnancy, autoimmune disease, renal disease, and chronic hypertension.Conclusions These factors and the underlying evidence base can be used to assess risk at booking so that a suitable surveillance routine to detect pre-eclampsia can be planned for the rest of the pregnancy.