Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat.
Anatomic evidence for a neurotoxic effect of (+/-)-fenfluramine upon serotonergic projections in the rat.
复制标题
(i)-芬氟拉明对大鼠血清素能投射的神经毒性作用的解剖学证据。
DOI：
10.1016/0006-8993(90)90237-6
复制
发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Molliver,ME
中科院分区：
文献类型：
--
作者：
Molliver,DC;Molliver,ME
Immunocytochemistry was used to determine whether (±)-fenfluramine causes structural damage to serotonergic (5-HT) neurons. Sections from rat forebrain were examined 4 h, 36 h and 2 weeks after various dose regimens of fenfluramine. At all time points there was a reduction of fine 5-HT axon terminals in the forebrain, while beaded axons were spared. The presence of markedly swollen, fragmented 5-HT axons 36 h after injection is indicative of axonal degeneration, and provides morphologic evidence for a neurotoxic effect of (±)-fenfluramine upon 5-HT axon terminals.
