Widespread Positive Direct and Indirect Effects of Regular Physical Activity on the Developing Functional Connectome in Early Adolescence
Widespread Positive Direct and Indirect Effects of Regular Physical Activity on the Developing Functional Connectome in Early Adolescence
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DOI：
10.1093/cercor/bhab126
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发表时间：
2021-05-14
期刊：
影响因子：
3.7
通讯作者：
Stamoulis, Catherine
中科院分区：
文献类型：
--
作者：
Brooks, Skylar J.;Parks, Sean M.;Stamoulis, Catherine
青春期是大脑神经回路（连接组）发生深刻但尚未完全理解的变化的时期，它很容易受到不健康体重等风险因素的影响，但可能受到定期体育锻炼等积极因素的保护。在来自青少年脑认知发展（ABCD）队列的5955名儿童（中位年龄=120个月，50.86%为女性）中，我们研究了体力活动对静息状态网络的直接和间接影响（通过对身体质量指数[BMI]的影响），静息状态网络是无处不在地影响认知功能的功能连接体的骨干。我们估计有规律的身体活动对网络连通性、效率、稳健性和稳定性有显著的积极影响
Adolescence is a period of profound but incompletely understood changes in the brain's neural circuitry (the connectome), which is vulnerable to risk factors such as unhealthy weight, but may be protected by positive factors such as regular physical activity. In 5955 children (median age=120 months; 50.86% females) from the Adolescent Brain Cognitive Development (ABCD) cohort, we investigated direct and indirect (through impact on body mass index [BMI]) effects of physical activity on resting-state networks, the backbone of the functional connectome that ubiquitously affects cognitive function. We estimated significant positive effects of regular physical activity on network connectivity, efficiency, robustness and stability (P