Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling
Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling
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DOI：
10.1016/j.bbrc.2009.10.113
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发表时间：
2009-12-18
影响因子：
3.1
通讯作者：
Itoh, Nobuyuki
中科院分区：
文献类型：
--
作者：
Miyake, Ayumi;Takahashi, Yohsuke;Itoh, Nobuyuki
在小鼠和人类中鉴定了编码新分泌蛋白的基因，并命名为Neucrin。小鼠Neucrin由343个氨基酸组成，在其羧基末端区域具有富含半胱氨酸的结构域。富含半胱氨酸的结构域中的10个半胱氨酸残基的位置与分泌型Writ拮抗剂Dickkopfs（Dkks）的位置相似。然而，Dkks有两个富含半胱氨酸的结构域，而Neucrin只有一个。Neucrin和Dkks与LDL受体相关蛋白6结合并抑制胞浆β-连环蛋白的稳定，表明Neucrin是经典Wnt信号传导的拮抗剂。在成年小鼠的任何主要组织中均未检测到小鼠Neucrin表达，但在发育中的神经组织（包括脑和脊髓）中检测到。Neucrin的表达模式不同于任何Dkk的表达模式。Neucrin是一种独特的分泌型Wnt拮抗剂，主要在发育中的神经组织中表达。(C)2009 Elsevier Inc. All rights reserved.
A gene encoding a novel secreted protein in mice and humans was identified, and named Neucrin. Mouse Neucrin consists of 343 amino acids with a cysteine-rich domain in its carboxyl terminal region. The positions of 10 cysteine residues in the cysteine-rich domain are similar to those of Dickkopfs (Dkks), secreted Writ antagonists. However, whereas Dkks have two cysteine-rich domains, Neucrin has only one. Neucrin as well as Dkks bound to LDL receptor-related protein 6 and inhibited the stabilization of cytosolic beta-catenin, indicating that Neucrin is an antagonist of canonical Wnt signaling. Mouse Neucrin expression was not detected in any major tissues in the adult, but was detected in developing neural tissues, including the brain and spinal cord. The expression pattern of Neucrin is distinct from that of any Dkk. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues. (C) 2009 Elsevier Inc. All rights reserved.