Co-occurring anxiety influences patterns of brain activity in depression.
Co-occurring anxiety influences patterns of brain activity in depression.
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DOI：
10.3758/cabn.10.1.141
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Miller GA
中科院分区：
文献类型：
--
作者：
Engels AS;Heller W;Spielberg JM;Warren SL;Sutton BP;Banich MT;Miller GA
在执行情绪词Stroop任务期间，通过fMRI测量与快感缺乏抑郁症和共同发生的焦虑唤醒和焦虑忧虑相关的脑激活。与脑电图结果一致，抑郁症与背外侧前额叶皮层（DLPFC）的额叶外侧化有关，但仅当焦虑唤醒升高和焦虑恐惧低时。在相同的条件下，抑郁症患者的右额下回（IFG）的活动也减少。相比之下，抑郁症与前扣带皮层（dACC和rACC）和双侧杏仁核的更多活动相关。结果表明，抑郁症，特别是当伴随着焦虑的觉醒，可能会导致未能实施自上而下的处理适当的大脑区域（左DLPFC，右IFG），由于增加激活区域与响应情绪显着的信息（右DLPFC，杏仁核）。
Brain activation associated with anhedonic depression and co-occurring anxious arousal and anxious apprehension was measured by fMRI during performance of an emotion-word Stroop task. Consistent with EEG findings, depression was associated with rightward frontal lateralization in dorsolateral prefrontal cortex (DLPFC), but only when anxious arousal was elevated and anxious apprehension was low. Activity in right inferior frontal gyrus (IFG) was also reduced for depression under the same conditions. In contrast, depression was associated with more activity in anterior cingulate cortex (dACC and rACC) and bilateral amygdala. Results imply that depression, particularly when accompanied by anxious arousal, may result in a failure to implement top-down processing by appropriate brain regions (left DLPFC, right IFG) due to increased activation in regions associated with responding to emotionally salient information (right DLPFC, amygdala).