New developments in the chemistry and biology of the bioactive constituents of Tanshen
New developments in the chemistry and biology of the bioactive constituents of Tanshen
复制标题
DOI：
10.1002/med.20077
复制
发表时间：
2007-01-01
影响因子：
13.3
通讯作者：
Lee, Kuo-Hsiung
中科院分区：
文献类型：
--
作者：
Wang, Xihong;Morris-Natschke, Susan L.;Lee, Kuo-Hsiung
丹参是丹参的根茎，在中国传统医学中用于多种治疗。丹参的主要成分包括水溶性酚酸类和亲脂性丹参酮类。酚酸类化合物具有抗氧化和抗凝血活性，而丹参酮类化合物具有抗菌、抗氧化和抗凝血活性。本文就丹参的化学成分及其生物活性的研究进展作一综述。这些化学和生物学研究继续增加我们对丹参传统临床应用的科学基础的理解，也有助于开发新的候选药物。最近，作者实验室发现了一种新化合物新丹参内酯，具有强的选择性抗乳腺癌活性。这种化合物可能成为开发有前途的抗乳腺癌临床试验候选药物的先导。(c)2006 Wiley Periodicals，Inc.
Tanshen, the rhizome of Salvia miltiorrhiza Bunge, has been used in Chinese traditional medicine (TCM) for multiple therapeutic remedies. The major constituents of Tanshen include water-soluble phenolic acids and lipophilic tanshinones. Phenolic acids possess antioxidant and anticoagulant activities, whereas tanshinones show antibacterial, antioxidant, and antineoplastic activities. This review will focus on recent developments concerning the chemical constituents of Tanshen and their biological activities. These chemical and biological studies continue to increase our understanding about a scientific basis for the traditional clinical use of Tanshen and can also contribute to the development of new drug candidates. Recently, in the author's laboratory, a new compound, neo-tanshinlactone, was discovered to have potent selective antibreast cancer activity. This compound might serve as a lead for developing promising antibreast cancer clinical trials candidates. (c) 2006 Wiley Periodicals, Inc.