Systematic Analysis of Hollow Fiber Model of Tuberculosis Experiments
Systematic Analysis of Hollow Fiber Model of Tuberculosis Experiments
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DOI：
10.1093/cid/civ425
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发表时间：
2015-08-15
影响因子：
11.8
通讯作者：
Gumbo, Tawanda
中科院分区：
文献类型：
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作者：
Pasipanodya, Jotam G.;Nuermberger, Eric;Gumbo, Tawanda
背景。体外中空纤维系统结核模型（HFS-TB）是十多年前与蒙特卡罗实验相结合提出的。从那时起，它已被用于进行大量的结核病药代动力学/药效学（PK/PD）研究，但尚未进行系统分析。我们进行了文献检索，以确定2000年1月1日至2012年12月31日期间发表的所有HFS-TB实验。没有按语言排除冠词。根据系统评价和荟萃分析首选报告项目（PRISMA）最小化偏倚。遵循报告系统评价的步骤。发表了22项HFS-TB研究，其中12项为联合治疗研究，10项为单一治疗研究。有4个独立的蒙特卡罗实验利用了HFS-TB的定量输出。所有的实验都报告了药物的药代动力学，这与人类的药代动力学基本一致。HFS-TB研究包括环境空气下的对数相生长研究，pH值为5.8的半休眠细菌，以及低氧张力下的非复制持久性细菌
Background. The in vitro hollow fiber system model of tuberculosis (HFS-TB), in tandem with Monte Carlo experiments, was introduced more than a decade ago. Since then, it has been used to perform a large number of tuberculosis pharmacokinetics/pharmacodynamics (PK/PD) studies that have not been subjected to systematic analysis.Methods. We performed a literature search to identify all HFS-TB experiments published between 1 January 2000 and 31 December 2012. There was no exclusion of articles by language. Bias minimization was according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Steps for reporting systematic reviews were followed.Results. There were 22 HFS-TB studies published, of which 12 were combination therapy studies and 10 were monotherapy studies. There were 4 stand-alone Monte Carlo experiments that utilized quantitative output from the HFS-TB. All experiments reported drug pharmacokinetics, which recapitulated those encountered in humans. HFS-TB studies included log-phase growth studies under ambient air, semidormant bacteria at pH 5.8, and nonreplicating persisters at low oxygen tension of