A PARATHYROID-HORMONE ANTAGONIST STIMULATES EPIDERMAL PROLIFERATION AND HAIR-GROWTH IN MICE
A PARATHYROID-HORMONE ANTAGONIST STIMULATES EPIDERMAL PROLIFERATION AND HAIR-GROWTH IN MICE
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DOI：
10.1073/pnas.91.17.8014
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发表时间：
1994-08-16
影响因子：
11.1
通讯作者：
PERSONS, KS
中科院分区：
文献类型：
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作者：
HOLICK, MF;RAY, S;PERSONS, KS
用体外培养的人角质形成细胞和SKH-1无毛小鼠研究了甲状旁腺激素（PTH）相关肽（PTHrP）在正常皮肤中的生物学作用。结果表明，PTHrP激动剂人PTHrP-(1-34)和PTH（1-34）是有效的表皮细胞增殖抑制剂。[Nle(8,18), Tyr(34)]牛PTH-(7-34)-酰胺是一种PTH/PTHrP受体拮抗剂，可阻断PTH-(1-34)在体外培养的角质形成细胞中的抑制作用。在SKH-1小鼠中，PTH-(7-34)使[H-3]胸腺嘧啶并入离体表皮DNA的数量增加244%，毛干的数量和长度分别增加246%和180%。因此，PTH和PTHrP可能在皮肤的正常生理中发挥重要作用，它们的激动剂和拮抗剂在治疗增生性皮肤疾病和皮肤老化方面具有潜在的广泛治疗应用，也可能有效地刺激和维持头发生长。
The biologic action of parathyroid hormone (PTH)-related peptide (PTHrP) in normal skin was investigated in cultured human keratinocytes and in SKH-1 hairless mice. The results indicate that the PTHrP agonists human PTHrP-(1-34) and PTH(1-34) are potent inhibitors of epidermal cell proliferation. [Nle(8,18), Tyr(34)]bovine PTH-(7-34)-amide, an antagonist of the PTH/PTHrP receptor, blocked the inhibitory effect of PTH-(1-34) in cultured keratinocytes. In the SKH-1 mice, PTH-(7-34) caused a 244% increase of [H-3]thymidine incorporation into isolated epidermal DNA and 246% and 180% increases in the number and length of hair shafts, respectively. Thus, PTH and PTHrP may play an important role in the normal physiology of skin, and their agonists and antagonists have potentially wide therapeutic applications in the treatment of hyperproliferative skin disorders and aging skin and could also be effective in stimulating and maintaining hair growth.