Determination of cortisol and dehydroepiandrosterone levels in saliva for screening of periodontitis in older Japanese adults.
Determination of cortisol and dehydroepiandrosterone levels in saliva for screening of periodontitis in older Japanese adults.
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DOI：
10.1155/2009/280737
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发表时间：
2009
影响因子：
2.1
通讯作者：
Takehara T
中科院分区：
文献类型：
--
作者：
Ansai T;Soh I;Ishisaka A;Yoshida A;Awano S;Hamasaki T;Sonoki K;Takata Y;Takehara T
背景最近的报告发现牙周炎与激素皮质醇和脱氢表雄酮（DHEA）呈正相关。我们调查了不吸烟者和吸烟者的老年受试者中这些水平与牙周炎之间的关系。主题和方法。测定了171名受试者（男性85名，女性86名）唾液中的皮质醇和DHEA水平，并进行了临床检查，包括探测深度（PD）和临床附着丧失（CAL）。结果吸烟对皮质醇和脱氢表雄酮水平有影响，并且与从不吸烟者的严重PD和CAL显著相关。根据ROC分析，皮质醇和DHEA检测重度牙周炎的最佳敏感性和特异性的截断值分别为2.06 ng/mL和60.24 pg/mL，分别为PD和2.12 ng/mL和61.78 pg/mL，CAL。激素水平的评估可能是一个有用的牙周炎筛查方法，但仅限于从不吸烟者。
Background. Recent reports have found a positive relationship between periodontitis and the hormones cortisol and dehydroepiandrosterone (DHEA). We investigated the associations between those levels and periodontitis in never-smokers and smokers of elderly subjects. Subjects and Methods. Cortisol and DHEA levels in saliva were determined in 171 subjects (85 males, 86 females), with clinical examinations including probing depth (PD) and clinical attachment loss (CAL) also performed. Results. Smoking had effects on cortisol and DHEA levels, and those were significantly associated with severe PD and CAL in never-smokers. According to ROC analysis, the cutoff values of cortisol and DHEA to obtain the optimal sensitivity and specificity for detecting severe periodontitis were 2.06 ng/mL and 60.24 pg/mL, respectively, for PD, and 2.12 ng/mL and 61.78 pg/mL, respectively, for CAL. Conclusions. Assessment of hormone levels may be a useful screening method for periodontitis, though limited to never-smokers.