Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems
Flash synthesis of TAC-101 and its analogues from 1,3,5-tribromobenzene using integrated flow microreactor systems
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DOI：
10.1039/c1ra00377a
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发表时间：
2011-10
期刊：
影响因子：
3.9
通讯作者：
A. Nagaki;K. Imai;Heejin Kim;J. Yoshida
中科院分区：
文献类型：
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作者：
A. Nagaki;K. Imai;Heejin Kim;J. Yoshida
采用由6个微混合器和6个微管反应器组成的集成流动微反应器系统，实现了基于Br/Li交换反应将3种亲电试剂顺序引入到1，3，5-三溴苯中.该方法能够在13 s内快速合成TAC-101及其类似物，在制备规模上具有良好的产率。
Sequential introduction of three electrophiles into 1,3,5-tribromobenzene based on Br/Li exchange reaction was achieved using an integrated flow microreactor system consisting of six micromixers and six microtube reactors. This method enables flash synthesis of TAC-101 and its analogues within 13 s in good yields on a preparative scale.