Moonlighting Motors: Kinesin, Dynein, and Cell Polarity.
Moonlighting Motors: Kinesin, Dynein, and Cell Polarity.
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DOI：
10.1016/j.tcb.2017.02.005
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发表时间：
2017-07
影响因子：
19
通讯作者：
Gelfand VI
中科院分区：
文献类型：
--
作者：
Lu W;Gelfand VI
除了众所周知的在细胞质中运输货物的作用外，微管马达还组织自己的轨道，即微管。虽然这种功能主要是在细胞分裂的背景下研究，但它对微管组织和间期细胞中细胞极性的产生至关重要。驱动蛋白-1是最丰富的微管马达，在神经突的初始形成中起作用。本文综述了驱动蛋白1驱动微管滑动的机制及其在神经元中的生物学意义。最近的研究描述驱动蛋白-1和细胞质动力蛋白之间的相互作用的微管易位进行了讨论。此外，我们评估最近的工作探索轴突生长和再生过程中微管滑动的发育调控。总的来说，讨论的作品表明，滑动的间期微管电机是一种新的力产生机制，重组细胞骨架和驱动器的形状变化和极化。
In addition to their well-known role in transporting cargoes in the cytoplasm, microtubule motors organize their own tracks, microtubules. While this function is mostly studied in the context of cell division, it is essential for microtubule organization and generation of cell polarity in interphase cells. Kinesin-1, the most abundant microtubule motor, plays a role in the initial formation of neurites. This review describes the mechanism of kinesin-1-driven microtubule sliding and discusses its biological significance in neurons. Recent studies describing the interplay between kinesin-1 and cytoplasmic dynein in translocation of microtubules are discussed. In addition, we evaluate recent work exploring the developmental regulation of microtubule sliding during axonal outgrowth and regeneration. Collectively, the discussed works suggest that sliding of interphase microtubules by motors is a novel force-generating mechanism that reorganizes the cytoskeleton and drives shape change and polarization.