CIRCULATING IMMUNE-COMPLEXES IN POLYMYALGIA RHEUMATICA AND GIANT-CELL ARTERITIS
CIRCULATING IMMUNE-COMPLEXES IN POLYMYALGIA RHEUMATICA AND GIANT-CELL ARTERITIS
复制标题
DOI：
10.1136/ard.40.4.360
复制
发表时间：
1981-01-01
影响因子：
27.4
通讯作者：
HAZLEMAN, BL
中科院分区：
文献类型：
--
作者：
PARK, JR;JONES, JG;HAZLEMAN, BL
巨细胞动脉炎和/或风湿性多肌痛患者的血清中含有增加水平的循环免疫复合物（IC）。聚乙二醇沉淀补体消耗（PEG-CC）试验的结果与疾病活动性相关。在活性未治疗组（21例患者）的样本中，44%的IC水平升高，而非活性治疗组（49例患者）的IC水平升高为23%。通过125 I-Clq结合、PEG-C4试验和结合试验中的125 I-结合物对循环IC进行进一步分析。虽然IC水平与疾病活动性之间的相关性不高，但IC的分离和分析可能会导致对这种疾病的进一步了解。
Sera from patients with giant cell arteritis and/or polymyalgia rheumatica contained increased levels of circulating immune complexes (IC). Results with the polyethyleneglycol precipitation complement consumption (PEG-CC) assay were correlated with disease activity. Of samples from an active untreated group (21 patients), 44% had increased levels of IC compared to 23% from an inactive treated group (49 patients). Further analysis of circulating IC was performed by 125I-Clq binding, the PEG-C4 test, and 125I-conglutinin binding assays. Although there was not a high correlation between IC levels and disease activity, isolation and analysis of the IC may lead to further understanding of this disorder.