Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
复制标题
DOI：
10.1073/pnas.95.2.548
复制
发表时间：
1998-01-20
影响因子：
11.1
通讯作者：
Stacker, SA
中科院分区：
文献类型：
--
作者：
Achen, MG;Jeltsch, M;Stacker, SA
我们已经确定了一个成员的血管内皮生长因子家族的基于计算机的同源性搜索，并已指定为VEGF-D。VEGF-D与VEGF-C最密切相关，因为存在在其他VEGF家族成员中未发现的N-和C-末端延伸。在成人组织中，VEGF-D mRNA在心脏、肺、骨骼肌、结肠和小肠中最丰富，VEGF-D受体特异性分析显示，VEGF-D是VEGF受体（VEGFR）VEGFR-2（Flk 1）和VEGFR-3（Flt 4）的配体。并且可以激活这些受体，然而，VEGF-D不结合VEGFR-1。VEGF-D的截短衍生物的表达表明，受体结合能力存在于分子的一级结构中与其他VEGF家族成员最密切相关的部分，并且对应于VEGF-C的成熟形式。此外，VEGF-D是内皮细胞的有丝分裂原。VEGF-D和VEGF-C之间的结构和功能相似性定义了VEGF的亚家族。
We have identified a member of the VEGF family by computer-based homology searching and have designated it VEGF-D. VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members, In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine, Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors, However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. The structural and functional similarities between VEGF-D and VEGF-C define a subfamily of the VEGFs.