MELATONIN IN SERUM AND THE PINEAL OF SPONTANEOUSLY HYPERTENSIVE RATS
MELATONIN IN SERUM AND THE PINEAL OF SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.3109/10641968409044066
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
SPECTOR, S
中科院分区：
文献类型：
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作者：
KAWASHIMA, K;NAGAKURA, A;SPECTOR, S
褪黑素作为一种内源性中枢降压因子参与血压调节，在大鼠和人中都有发现。用灵敏、特异的放射免疫法，结合一种新的提取方法，测定了5周龄和15周龄自发性高血压(SHR)和正常血压Wistar京都(WKY)大鼠的血清和松果体浓度，研究了褪黑素与高血压发生发展的关系。幼年SHR大鼠午夜血清褪黑素浓度显著高于同龄WKY大鼠(P<；0.01)，而成年SHR大鼠血清褪黑素浓度显著低于成年SHR(P<；0.01)。中午没有观察到这样的差异。5周龄SHR大鼠午夜松果体褪黑素含量低于同龄WKY大鼠(P<；0.01)。可见，SHR大鼠夜间血清褪黑素在高血压前期升高，高血压形成后下降。褪黑素在自发性高血压大鼠高血压过程中的作用有待进一步研究。
Involvement of melatonin in the blood pressure regulation as an endogenous central hypotensive factor has been suggested in rats and in man. The relationship between melatonin and the development of hypertension in 5- and 15-wk-old spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats was studied by measuring serum and the pineal concentrations with a sensitive and specific radioimmunoassay coupled with a novel extraction method. Serum melatonin concentration at midnight in young SHR rats was significantly higher than that in age-matched WKY rats, (P < 0.01), whereas it was decreased in the adult SHR (P < 0.01). No such diffferences were observed at noon. Pineal content of melatonin at midnight in 5-wk-old SHR rats was lower than in age-matched WKY rats (P < 0.01). Evidently, melatonin in the nocturnal serum of SHR rats is elevated at prehypertensive stage while it is decreased after the development of hypertension. The role of melatonin in the hypertensive process in SHR rats requires further study.