Georges Marinesco and the early research in neuropathology
Georges Marinesco and the early research in neuropathology
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DOI：
10.1212/01.wnl.0000338626.93425.74
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发表时间：
2009-01-06
期刊：
影响因子：
9.9
通讯作者：
Curca, G. C.
中科院分区：
文献类型：
--
作者：
Buda, O.;Arsene, D.;Curca, G. C.
Objective: To present the scientific contributions of Georges Marinesco (1863-1938) and place his achievements within the context of early neuropathology research.Background: Neuropathology is a relatively recent medical field, its origins dating to the late 19th century.Results: One of the most important neuroscientists of that period was the Romanian-born Georges Marinesco. He became a neurologist under Charcot's guidance at the Salpetriere Hospital, in Paris. In 1892, Paul Blocq and Marinesco gave a first account of senile plaques, having used their pathologic skills in the examination of nine deceased epileptic patients. They did not, however, relate the plaques to dementia. Marinesco made discoveries in neuropathology which he described from a histopathologic perspective, and introduced new medical terms such as neuronophagia, chromatolysis, and medullomyoblastoma. He also drew correlations between clinical neurologic findings and morphology, for example in congenital cerebellar ataxia, syringomyelia, and parkinsonism. From 1899 he used cinematography as a medical research tool.Conclusion: Marinesco was a prolific researcher in the field of neuropathology, especially neurodegeneration but also in clinical neurology. He is now considered the founder of the modern Romanian school of neurology. Neurology (R) 2009; 72: 88-91
