Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity.
Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity.
复制标题
DOI：
10.4049/jimmunol.138.11.3720
复制
发表时间：
1987-06
影响因子：
4.4
通讯作者：
O. Martínez-Maza;E. Crabb;R. Mitsuyasu;J. Fahey;J. Giorgi
中科院分区：
文献类型：
--
作者：
O. Martínez-Maza;E. Crabb;R. Mitsuyasu;J. Fahey;J. Giorgi
采用双色流式细胞术检测了获得性免疫缺陷综合征（AIDS）患者、人类免疫缺陷病毒（HIV）血清阳性个体和健康血清阴性供体B淋巴细胞表型标志物的表达。与未感染HIV的供者相比，艾滋病患者和HIV血清阳性个体的B细胞携带活化标志物转铁蛋白受体的百分比升高。在AIDS患者和HIV血清阳性个体中也观察到静息（Leu-8阳性）B细胞百分比的降低。在艾滋病患者中观察到循环中未成熟（CALLA阳性，CD 10）B细胞百分比增加。这些表型变化伴随着自发IgG和IgM分泌水平的增加，以及总B细胞群和某些B细胞亚群中细胞大小的增加，在AIDS患者和HIV血清阳性人群中。这些结果表明，在体内B细胞活化和不成熟的表型变化的指示伴随着多克隆生产的IG中看到的HIV感染的个人。
The expression of phenotypic markers on B lymphocytes in patients with the acquired immune deficiency syndrome (AIDS), in human immunodeficiency virus (HIV) seropositive individuals, and in healthy seronegative donors was examined by two-color flow cytometry. Patients with AIDS and HIV-seropositive individuals showed an elevated percentage of B cells bearing an activation marker, the transferrin receptor, when compared with donors not infected with HIV. A decrease in the percentage of resting (Leu-8 positive) B cells was also seen in AIDS patients and HIV-seropositive individuals. An increased percentage of circulating, immature (CALLA-positive, CD10) B cells was seen in AIDS patients. These phenotypic changes were accompanied by an increased level of spontaneous IgG and IgM secretion, and increased cell size within the total B cell population and in some B cell subpopulations, in patients with AIDS and in HIV-seropositive people. These results demonstrate that phenotypic changes indicative of in vivo B cell activation and immaturity accompany the polyclonal production of Ig seen in HIV-infected individuals.