Prenatal findings incongenital leukemia : a case report
Prenatal findings incongenital leukemia : a case report
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产前检查结果非先天性白血病：病例报告
DOI：
10.1159/000323582
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发表时间：
2011
期刊：
影响因子：
2.2
通讯作者：
Fujiwara H and Konishi I
中科院分区：
文献类型：
--
作者：
Sato Y;Izumi Y;Minegishi K;Komada M;Yamada S;Kakui K;Tatsumi K;Mikami Y;Fujiwara H and Konishi I
我们在这里描述一个先天性白血病的情况下，终止在子宫内胎儿死亡，在妊娠30周。胎儿躯干急剧增大、脐动脉脉动指数升高，同时大脑中动脉脉动指数下降、胸腔积液和羊水过多是胎儿死亡的先兆。胎盘组织的显微镜检查提示先天性骨髓性白血病的诊断，显示未成熟的骨髓前体充满脐带和绒毛膜绒毛中的胎儿血管腔。白血病细胞广泛累及胎盘血管被认为是胎儿死亡的主要原因。
We here describe a case of congenital leukemia that ended in intrauterine fetal demise at 30 weeks of gestation. Acute enlargement of the fetal trunk, elevated pulsatility index of the umbilical artery with concomitant decline of pulsatility index of the middle cerebral artery, pleural effusion, and polyhydramnios preceded the fetal death. Diagnosis of congenital myeloid leukemia was suggested by microscopic examination of the placental tissue, revealing immature myeloid precursors filling the lumina of fetal vessels in the umbilical cord and chorionic villi. Extensive vascular involvement of the placenta by leukemic cells was considered to be a primary cause of the fetal death.