INTERACTIONS BETWEEN SYMPATHETIC VASOCONSTRICTOR OUTFLOW AND C-NOCICEPTOR-INDUCED ANTIDROMIC VASODILATATION
INTERACTIONS BETWEEN SYMPATHETIC VASOCONSTRICTOR OUTFLOW AND C-NOCICEPTOR-INDUCED ANTIDROMIC VASODILATATION
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DOI：
10.1016/0304-3959(93)90208-7
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发表时间：
1993-08-01
期刊：
影响因子：
7.4
通讯作者：
CLINE, M
中科院分区：
文献类型：
--
作者：
OCHOA, JL;YARNITSKY, D;CLINE, M
本文研究了刺激C纤维的顺行交感血管收缩药与逆行血管舒张剂之间的相互作用。C纤维的兴奋是通过对上肢神经进行间歇性疼痛神经内微刺激来实现的，同时记录皮肤感觉投射区域的皮肤热发射曲线。在最初的刺激过程中，当两个系统共同激活时，皮肤温度会下降。刺激结束后，温度升高。最终，在重新刺激后，体温再次下降。因此，交感血管收缩被发现盖过了刺激C伤害性感受器所引起的逆行血管扩张效应。在解释周围神经疾病患者的皮肤温度异常偏差时，必须考虑交感神经和躯体系统驱动的相反血管舒缩效应之间的动态相互作用。
The interaction between orthodromic sympathetic vasoconstrictor and antidromic vasodilator effects of C-fiber stimulation was studied in normal human volunteers. Excitation of C fibers was achieved through administration of intermittent painful intraneural microstimulation to upper limb nerves, while recording cutaneous thermal emission profiles in the projected fields of cutaneous sensation. During initial stimulation, when both systems are co-activated, skin temperature decreased. Temperature increased after termination of the stimulus. Eventually, temperature decreased again upon renewed stimulation. Thus, sympathetic vasoconstriction was found to override the antidromic vasodilator effect induced by stimulation of C nociceptors. When interpreting abnormal deviations of skin temperature in patients with peripheral nerve disorders, the dynamic interplay between opposing vasomotor effects driven by sympathetic and somatic systems must be taken into consideration.