Metabolic fate of diethylstilbestrol in the Syrian golden hamster, a susceptible species for diethylstilbestrol carcinogenicity.
Metabolic fate of diethylstilbestrol in the Syrian golden hamster, a susceptible species for diethylstilbestrol carcinogenicity.
复制标题
叙利亚金仓鼠中己烯雌酚的代谢命运，叙利亚金仓鼠是己烯雌酚致癌的易感物种。
DOI：
10.3109/00498258009033763
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
M. Metzler
中科院分区：
文献类型：
--
作者：
R. Gottschlich;M. Metzler
1. 叙利亚金仓鼠口服己烯雌酚后，雄性优先从粪便中排出，雌性则在尿液和粪便中排出量大致相等。葡萄糖苷酸是男女尿液中主要的结合物。 2. 在尿葡萄糖苷酸组分中鉴定出己烯雌酚的 11 种氧化代谢物。它们代表己烯雌酚、拟己烯雌酚和二烯雌酚的脂肪族羟基、芳香族羟基和芳香族甲氧基衍生物。 3.仓鼠体内己烯雌酚氧化代谢无性别差异。 4. 提供并讨论了各种代谢物的详细色谱和质谱信息。
1. Diethylstilbestrol, after oral administration to Syrian golden hamsters, is preferentially excreted in the faeces in males, and in about equal amounts in urine and faeces in females. Glucuronides comprise the major urinary conjugate for both sexes. 2. Eleven oxidative metabolites of diethylstilbestrol have been identified in the urinary glucoronide fraction. They represent aliphatic hydroxy-, aromatic hydroxy-, and aromatic methoxy-derivatives of diethylstilbestrol, pseudo diethylstilbestrol, and dienestrol. 3. No sex difference in the oxidative metabolism of diethylstilbestrol was observed in the hamster. 4. Detailed chromatographic and mass spectrometric information on the various metabolites is provided and discussed.