Transition metal catalysed reactions of alcohols using borrowing hydrogen methodology
Transition metal catalysed reactions of alcohols using borrowing hydrogen methodology
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DOI：
10.1039/b813383b
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发表时间：
2009-01-01
影响因子：
4
通讯作者：
Williams, Jonathan M. J.
中科院分区：
文献类型：
--
作者：
Nixon, Tracy D.;Whittlesey, Michael K.;Williams, Jonathan M. J.
醇的反应性可以通过使用过渡金属催化剂暂时除去氢以生成中间体醛或酮来增强。如此形成的羰基化合物对亲核加成具有更大的反应性，从而适应亚胺或烯烃的原位形成。从催化剂返回的氢导致新的C-N和C-C键的形成，通常水是唯一的反应副产物。
The reactivity of alcohols can be enhanced by the temporary removal of hydrogen using a transition metal catalyst to generate an intermediate aldehyde or ketone. The so-formed carbonyl compound has a greater reactivity towards nucleophilic addition accommodating the in situ formation of imines or alkenes. The return of hydrogen from the catalyst leads to the formation of new C-N and C-C bonds, often with water as the only reaction by-product.