The role and mechanisms of miRNA in neonatal necrotizing enterocolitis.
The role and mechanisms of miRNA in neonatal necrotizing enterocolitis.
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miRNA在新生儿坏死性小肠结肠炎中的作用及机制
DOI：
10.3389/fped.2022.1053965
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发表时间：
2022
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
新生儿坏死性小肠结肠炎（NEC）是一种急性肠道炎症疾病，是新生儿死亡的最重要原因。目前，尚不清楚这种疾病到底是如何引起的，但有人认为，这种疾病是早产、肠内喂养、不适当的促炎症反应和肠道细菌感染之间复杂相互作用的结果。微小RNA（miRNA）是一类内源性非编码单链RNA，长约23个核苷酸，参与基因表达的调节。最近，大量研究已经确定异常的miRNA表达在包括NEC在内的多种疾病中发挥着重要作用。在这里，我们总结了 miRNA 在 NEC 中的作用。我们介绍了miRNA的生物合成和功能，然后描述了miRNA在NEC发生和发展中的可能机制，包括它们对肠上皮屏障功能和炎症过程调节的影响。最后，本综述有助于全面了解当前的miRNA，以准确预测NEC的诊断，并为寻找miRNA对NEC的潜在治疗靶点提供思路。总之，我们的目的是强调 miRNA 与 NEC 之间的密切关系，并总结开发 NEC 诊断生物标志物和潜在治疗靶点的实用价值。
Neonatal necrotizing enterocolitis (NEC), the most significant causes of neonatal mortality, is a disease of acute intestinal inflammation. At present, it is not clear exactly how the disease is caused, but it has been suggested that this disorder is a result of a complex interaction among prematurity, enteral feeding and inappropriate pro-inflammation response and bacterial infection of the intestine. A microRNA (miRNA) is a class of endogenous non-coding single-stranded RNA that is about 23 nucleotides long engaging in the regulation of the gene expression. Recently, numerous studies have determined that abnormal miRNA expression plays important roles in various diseases, including NEC. Here, we summarized the role of miRNAs in NEC. We introduce the biosynthetic and function of miRNAs and then describe the possible mechanisms of miRNAs in the initiation and development of NEC, including their influence on the intestinal epithelial barrier's function and regulation of the inflammatory process. Finally, this review aids in a comprehensive understanding of the current miRNA to accurately predict the diagnosis of NEC and provide ideas to find potential therapeutic targets of miRNA for NEC. In conclusion, our aims are to highlight the close relationship between miRNAs and NEC and to summarize the practical value of developing diagnostic biomarkers and potential therapeutic targets of NEC.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
MiR-146a-5p 模拟物抑制新生儿坏死性小肠结肠炎中的 NLRP3 炎性体下游炎症因子和 CLIC4
影响因子：
5.5
作者：
Chen J;Chen T;Zhou J;Zhao X;Sheng Q;Lv Z
通讯作者：
Lv Z
DOI：
10.1590/1414-431x20143857
发表时间：
2014-09
期刊：
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
影响因子：
--
作者：
Yang Y;Guo Y;Kan Q;Zhou XG;Zhou XY;Li Y
通讯作者：
Li Y
影响因子：
2.4
作者：
Galley JD;Mar P;Wang Y;Han R;Rajab A;Besner GE
通讯作者：
Besner GE
影响因子：
2.5
作者：
Gilfillan, Margaret;Bhandari, Vineet
通讯作者：
Bhandari, Vineet