Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men
Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men
复制标题
DOI：
10.1161/01.cir.100.2.123
复制
发表时间：
1999-07-13
期刊：
影响因子：
37.8
通讯作者：
Kuusisto, J
中科院分区：
文献类型：
--
作者：
Lempiäinen, P;Mykkänen, L;Kuusisto, J
背景-胰岛素抵抗综合征特有的一组危险因素作为冠心病(CHD)的预测因子的作用以前没有研究过。方法和结果-通过因子分析对心血管危险因素的聚集进行分析，以调查这些聚集(因素)是否预测CHD事件(CHD死亡或非致命性心肌梗死)，对来自芬兰东部的1069名65-74岁的非糖尿病人群进行了7年的随访。在随访期内有151例冠心病事件(男性92例，女性59例)。在男性中，因子1(胰岛素抵抗因子，主要反映体重指数、腰臀比、甘油三酯、空腹血糖和胰岛素)(危险比[HR]，95%CI，1.33，CI 1.08，1.65，P=0.008)，因子2(饮酒，高密度脂蛋白胆固醇，低甘油三酯)(HR0.78，CI 0.63，0.96，P=0.020)，因子3(年龄，收缩压，尿白蛋白/肌酐比，左心室肥厚)(HR 1.52，CI 1.26，1.83，P
Background-The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously.Methods and Results-Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (factors) predict CHD events (CHD death or nonfatal myocardial infarction) in a nondiabetic population of 1069 subjects 65 to 74 years old from eastern Finland followed up for 7 years. There were 151 CHD events (92 for men, 59 for women) during the follow-up period. In men, factor 1 (the insulin resistance factor, which reflected primarily body mass index, waist-to-hip ratio, triglycerides, fasting plasma glucose, and insulin) (hazards ratio [HR] with 95% CI, 1.33, CI 1.08, 1.65, P=0.008), factor 2 (alcohol consumption, high HDL cholesterol, low triglycerides) (HR 0.78, CI 0.63, 0.96, P=0.020), factor 3 (age, systolic blood pressure, urinary albumin/creatinine ratio, left ventricular hypertrophy) (HR 1.52, CI 1.26, 1.83, P