Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers.
Physical activity in relation to cancer of the colon and rectum in a cohort of male smokers.
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发表时间：
2001-03
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通讯作者：
L. Colbert;T. Hartman;T. Hartman;N. Malila;P. Limburg;P. Pietinen;J. Virtamo;P. Taylor;D. Albanes
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作者：
L. Colbert;T. Hartman;T. Hartman;N. Malila;P. Limburg;P. Pietinen;J. Virtamo;P. Taylor;D. Albanes
我们在一组男性吸烟者中研究了职业和休闲体力活动与结直肠癌之间的关联。在α-生育酚、β-胡萝卜素癌症预防研究中，在 29,133 名 50-69 岁男性中，在长达 12 年的随访期间记录了 152 例结肠癌和 104 例直肠癌。对于结肠癌，与久坐的工人相比，从事轻度职业活动的男性的相对风险 (RR) 为 0.60 [95% 置信区间 (CI)，0.34-1.04]，而从事中度/重度活动的男性的 RR 为 0.45（CI，0.26-0.78；趋势 P，0.003）。亚位点分析显示，远端结肠与中度/重度职业活动显着相关（RR，0.21；CI，0.09-0.51），但与近端结肠无关（RR，0.87；CI，0.40-1.92）。休闲活动与结肠癌之间没有显着关联（活动与久坐；RR，0.82；CI，0.59-1.13）；然而，最强的负关联出现在那些工作和休闲最活跃的人中（RR，0.33；CI，0.16-0.71）。对于直肠癌，轻度职业活动（RR，0.71；CI，0.36-1.37）和中度/重度职业活动（RR，0.50；CI，0.26-0.97；趋势 P，0.04）的风险降低，与休闲活动无关。这些数据为体力活动对结肠癌和直肠癌的保护作用提供了证据。
We examined the association between occupational and leisure physical activity and colorectal cancer in a cohort of male smokers. Among the 29,133 men aged 50-69 years in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study,152 colon and 104 rectal cancers were documented during up to 12 years of follow-up. For colon cancer, compared with sedentary workers, men in light occupational activity had a relative risk (RR) of 0.60 [95% confidence interval (CI), 0.34-1.04], whereas those in moderate/heavy activity had an RR of 0.45 (CI, 0.26-0.78; P for trend, 0.003). Subsite analysis revealed a significant association for moderate/heavy occupational activity in the distal colon (RR, 0.21; CI, 0.09-0.51) but not in the proximal colon (RR, 0.87; CI, 0.40-1.92). There was no significant association between leisure activity and colon cancer (active versus sedentary; RR, 0.82; CI, 0.59-1.13); however, the strongest inverse association was found among those most active in both work and leisure (RR, 0.33; CI, 0.16-0.71). For rectal cancer, there were risk reductions for those in light (RR, 0.71; CI, 0.36-1.37) and moderate/heavy occupational activity (RR, 0.50; CI, 0.26-0.97; P for trend, 0.04), and no association for leisure activity. These data provide evidence for a protective role of physical activity in colon and rectal cancer.