Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
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DOI：
10.2131/jts.27.57
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发表时间：
2002-02-01
期刊：
影响因子：
--
通讯作者：
Shirai, Tomoyuki
中科院分区：
文献类型：
--
作者：
Hagiwara, Akihiro;Yoshino, Hiroko;Shirai, Tomoyuki
用1，2-二甲基肼处理雄性F344/DuCrj大鼠，在饲料中加入2-amino-1-methyl-6-phenylimidazo[4，5-b]pyridine(PhIP)，研究了天然花色苷食物色素--紫甘薯色和红甘蓝色对大鼠结直肠癌变的影响。DMH开始后，PSPC和RCC以5.0%的日粮水平与0.02%的PhIP配合使用，直到36周。未发现PSPC或RCC治疗相关的临床体征和体重变化。PhIP能明显增加DMH诱发的大鼠结直肠腺瘤和结直肠癌的发生率和多发性。相反，RCC抑制病变发展，或PSPC给药倾向于抑制病变发展。此外，在非DMH启动组，补充RCC可显著减少PhIP诱导的异常隐窝病灶(ACF)。结果表明，虽然PhIP对DMH诱发的结直肠癌有明显的促进作用，但在本实验条件下，饲料中添加5.0%的PSPC或5.0%的RCC可以降低这些作用。
The potential of purple sweet potato color (PSPC) and red cabbage color (RCC), natural anthocyanin food colors, to modify colorectal carcinogenesis was investigated in male F344/DuCrj rats, initially treated with 1,2-dimethylhydrazine (DMH) and receiving 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the diet. After DMH initiation, PSPC and RCC were given at a dietary level of 5.0% in combination with 0.02% PhIP until week 36. No PSPC or RCC-treatment-related changes in clinical signs and body weight were found. Incidences and multiplicities of colorectal adenomas and carcinomas in rats initiated with DMH were clearly increased by PhIP. In contrast, lesion development was suppressed by RCC, or tended to be inhibited by PSPC administration. Furthermore, in the non-DMH initiation groups, induction of aberrant crypt foci (ACF) by PhIP was significantly decreased by RCC supplementation. The results thus demonstrate that while PhIP clearly exerts promoting effects on DMH-induced colorectal carcinogenesis, these can be reduced by 5.0% PSPC or 5.0% RCC in a diet under the present experimental conditions.