Chiral Bronsted acid-catalyzed hydrophosphonylation of imines-DFT study on the effect of substituents of phosphoric acid
Chiral Bronsted acid-catalyzed hydrophosphonylation of imines-DFT study on the effect of substituents of phosphoric acid
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DOI：
10.1016/j.tet.2009.03.023
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发表时间：
2009-06-27
期刊：
影响因子：
2.1
通讯作者：
Hirata, Takashi
中科院分区：
文献类型：
--
作者：
Akiyama, Takahiko;Morita, Hisashi;Hirata, Takashi
利用手性磷酸催化亚磷酸二异丙酯与醛亚胺的对映选择性氢膦酰化反应，合成了高对映选择性的α-氨基膦酸酯。对磷酸的3，3 ′-取代基效应的DFT计算揭示了高对映选择性的原因。(C)2009爱思唯尔有限公司版权所有，
The enantioselective hydrophosphonylation reaction of diisopropyl phosphite with aldimine furnished alpha-amino phosphonates with high enantioselectivities by means of a chiral phosphoric acid. DFT calculation of the effect of 3,3'-substituents of the phosphoric acid revealed the reason for the high enantioselectivities. (C) 2009 Elsevier Ltd. All rights reserved,