Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance.
Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance.
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葡萄糖储存是具有正常糖耐量的受试者体内“胰岛素抵抗”的主要决定因素。
DOI：
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发表时间：
1986
影响因子：
5.8
通讯作者：
C. Bogardus
中科院分区：
文献类型：
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作者：
S. Lillioja;D. Mott;J. Zawadzki;A. Young;W. Abbott;C. Bogardus
体内对胰岛素对葡萄糖摄取作用的“抵抗”通常见于肥胖症，并且是肥胖受试者中非胰岛素依赖型糖尿病的特征。为了研究正常糖耐量受试者的葡萄糖摄取、葡萄糖氧化和非氧化性葡萄糖处置（储存）之间的关系，我们研究了25名高加索人和79名美国西南部印第安人，包括两组中的瘦型和肥胖型受试者。采用正葡萄糖钳夹技术和同步间接量热法测定葡萄糖摄取率和葡萄糖氧化率。这些研究以两种胰岛素输注速率（40和400 mU/m2 X min）进行，得到的平均血浆胰岛素浓度分别为113和1839 microU/ml。在较低的胰岛素输注速率下，葡萄糖摄取率约为2.2 mg/kg去脂质量X min的受试者中没有葡萄糖储存。相反，在相似胰岛素浓度下研究的葡萄糖摄取率超过7.0 mg/kg去脂质量X min的受试者中，葡萄糖储存占葡萄糖处置的45%以上。在高胰岛素输注速率下，葡萄糖处理能力低或高的受试者之间葡萄糖摄取差异的70%以上是由于葡萄糖储存。这些研究表明，在生理和最大刺激血浆胰岛素浓度的正常受试者中，葡萄糖储存是区分胰岛素介导的葡萄糖处置速率低或高的主要因素。由于葡萄糖储存可能是一个特定的激活过程，我们假设，未能激活葡萄糖储存是一个主要的缺陷，导致体内胰岛素抵抗的受试者与正常的葡萄糖耐量。
In vivo "resistance" to the action of insulin on glucose uptake is commonly found in obesity and is characteristic of noninsulin-dependent diabetes mellitus in obese subjects. To investigate the relationship among glucose uptake, glucose oxidation, and nonoxidative glucose disposal (storage) in subjects with normal glucose tolerance, we studied 25 caucasians and 79 southwestern American Indians, including lean and obese subjects in both groups. The euglycemic clamp technique with simultaneous indirect calorimetry was used to determine rates of glucose uptake and glucose oxidation. These studies were performed at two rates of insulin infusion (40 and 400 mU/m2 X min), with resulting mean plasma insulin concentrations of 113 and 1839 microU/ml, respectively. At the lower insulin infusion rate, there was no glucose storage in subjects with a glucose uptake rate of about 2.2 mg/kg fat free mass X min. In contrast, glucose storage accounted for over 45% of the glucose disposal in subjects with glucose uptake rates over 7.0 mg/kg fat free mass X min studied at similar insulin concentrations. At the high insulin infusion rate, over 70% of the difference in glucose uptake between subjects with a low or high capacity for glucose disposal was due to glucose storage. These studies demonstrated that in normal subjects at both physiological and maximally stimulating plasma insulin concentrations, glucose storage is a major factor in distinguishing between those with low or high rates of insulin-mediated glucose disposal. Since glucose storage may be a specifically activated process, we hypothesize that failure to activate glucose storage is a major defect causing in vivo insulin resistance in subjects with normal glucose tolerance.
影响因子：
15.9
作者：
FERRANNINI, E;SMITH, JD;DEFRONZO, RA
通讯作者：
DEFRONZO, RA